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2021 招收 CSC PhD (PSL-ChimieParistech)
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2021 招收 CSC PhD (PSL-ChimieParistech) Field: Chemistry, Physical Chemistry and Chemical Engineering, Life Science and Engineering for Agriculture, Food and the Environment Subfield: Electrochemistry, Bio analytical chemistry Title: Hydrogel Matrix Grafted electrochemical Aptasensors for the Detection of emerging pollutants ParisTech School: Chimie ParisTech Advisors Name: Cyrine Slim, Sophie Griveau, Fethi Bedioui Advisors Email: Cyrine.slim@chimieparistech.psl.eu/sophie.griveau@chimieparistech.psl.eu Research group/Lab: Institute of Chemistry for Life and Health Sciences, i-CLeHS Lab location : ENSCP Chimie Paristech 11, rue Pierre et Marie Curie 75231 Paris Cedex 05, France Lab website: https://iclehs.fr/research/seisad/ Short description of possible research topics for a PhD: Driven by the growing concern about the release of the untreated emerging pollutants and the urgent demand of determining low level of these pollutants present in environment, novel biosensors dedicated to molecular recognition will be developed. The objective of the project is to design biosensors using a novel class of grafted polymers, surface-attached hydrogel thin films on conductive transducer as biocompatible matrix for biomolecule immobilization. From biomolecules, aptamers constitute an attractive alternative to antibodies due to their high affinity and their excellent specificity for a target or a family of selected targets. It is also possible to functionalize them with specific chemical functions and/or with tag to label the aptamers, for their further immobilization and/or for their analysis. The immobilization of the aptamer onto surface-attached hydrogel thin films by covalent attachment provides a biodegradable shelter, providing the aptamer excellent environments to preserve its active and functional structure while allowing the detection of pollutants. For improved sensitivity and higher stability of the sensor, a high density of immobilized aptamer is enabled. Within a constant miniaturization effort, we will tend towards the transposition of this work, towards microfluidic electrochemical biosensors on real samples due to their miniature, portable and low-cost systems as well as high through put and automation. The integration of electrochemical sensors into microfluidic formats with the incorporation of unique materials for detection will be explored in this project. The development of these systems would lead to significant advantages compared to the current analytic systems, in terms of simplicity, speediness, cost, and automation. Required background of the student: Physical chemistry, ideally background in basic electrochemistry If you are interested in this projects, please contact Cyrine Slim, Sophie Griveau, 或者可以留帖给我。 |
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