| 查看: 697 | 回复: 2 | |||
letterman新虫 (小有名气)
|
[交流]
Postdoc position in Med Chem, McGill University, Canada
|
|
Position: Postdoctoral fellow in Medicinal Chemistry, under the supervision of Dr. Jian Hui Wu, Lady Davis Institute, McGill University, Montreal, Canada. Project description: Our laboratory is interested in identification and optimization of novel inhibitors against cancer targets. As a key member of our team, the candidate is expected to chemically optimize the initial active compounds. We routinely utilize structure-based approaches to identify top-ranking analogues to be synthesized. Our laboratory includes three components: structure-based drug design, Medicinal chemistry and biological evaluations. The funded projects are as follows: 1) Postdoc position 1: The start time is OCT, 2020. This funded project is to develop novel inhibitors of RanGTPase for ovarian cancer. Our preliminary work has discovered initial hits as novel inhibitors of RanGTPase, which are selectively active against the ovarian cancer cells, with no obvious effects on normal cells. 2) Postdoc position 2: The start time is NOV, 2020. This funded project is to develop novel modulators of Keap1/Nrf2 protein-protein interaction for lung cancer. Keap1 is an endogenous inhibitor of Nrf2. In normal cells, complexation of Keap1 with Nrf2 lead to Nrf2 degradation, resulting in basal level of Nrf2. However, mutation in Keap1 leads to Keap1 mutant that is unable to form a complex with Nrf2, resulting in high level of Nrf2 in cancer cells, which confer drug resistance in cancer patients. Our project is to discover compounds that could repair the interaction of Keap1 mutant with Nrf2, with a view to selectively suppressing Nrf2 level in cancer cells, which subsequently sensitize cancer cells to cancer treatment. We have already discovered initial hits that are selectively active against the Keap1 mutants, which are found in cancer cells, but have no effect on the wild-type Keap1, that are found in normal cells. Qualifications: We are looking for someone who is interested in anticancer drug discovery. The candidate should have a Ph.D. degree in Organic Chemistry/Medicinal Chemistry, which was obtained in 2018 or later. Language required: English Contact: Interested individuals should send a cover letter, CV and the coordinates of 2-3 referees to Dr. Jian Hui Wu (email address: Jian.H.Wu@McGill.CA). |
回复此楼» 猜你喜欢
估计是周四
已经有3人回复
-
基金啊基金
已经有3人回复
-
科研孤儿太难了
已经有15人回复
-
让我中一个面上吧！
已经有10人回复
-
言之凿凿，明天官网会通知放榜？
已经有17人回复
-
时间戳又变了
已经有17人回复
-
今天系统多次维护，明天很可能放榜！
已经有11人回复
-
时间戳变了，能看出什么问题？
已经有23人回复
-
只有每年这种时候来逛逛小木虫
已经有22人回复
-
放榜前的不淡定
已经有12人回复
海之蓝
银虫 (著名写手)
- 应助: 6 (幼儿园)
- 金币: 1267.5
- 散金: 224
- 红花: 18
- 帖子: 2166
- 在线: 1240.7小时
- 虫号: 1206449
- 注册: 2011-02-19
- 专业: 胶体与界面化学
2楼2020-09-19 11:18:30
letterman
新虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 288.3
- 帖子: 60
- 在线: 3小时
- 虫号: 23499739
- 注册: 2020-09-08
- 性别: GG
- 专业: 药物设计与药物信息
3楼2020-09-21 23:52:41
40