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Thank you for submitting your manuscript for publication in the American Chemical Society journal Biomacromolecules. It has been examined by expert reviewers whose reviews are enclosed.
We regret to inform you that we are unable to accept your manuscript for publication in Biomacromolecules. The results of the reviewers are mixed. Aside from the positive comments of the reviewers, we are particularly concerned by the low ratings given by both reviewers in regard to the novelty of the research reported. In addition, one reviewer gave marginal ratings to the overall importance of your manuscript to the field of biomacromolecules and the interest to scientists working in the field of biomacromolecules.
I am sorry to have to convey this decision to you. Nevertheless, we appreciate your choice of Biomacromolecules as a possible forum for presentation of your work and would be happy to consider other manuscripts from your laboratory.

Reviewer(s)' Comments to Author:
Reviewer: 1
Recommendation: Publish after major revisions noted.
Comments:
See attached comments
Please rate the overall importance of this manuscript to the field of biomacromolecules (10 �High Importance/ 1 �Low Importance): 6

Please rate the element of novelty in the research reported (10 - High Novelty / 1 - Low Novelty): 6
Please rate the interest to scientists working in the field of biomacromolecules (10 - High Interest / 1 - Low Interest): 6
Please rate the focus of the manuscript on the interface of polymer science and the biological sciences (10 - High Focus / 1 - Low Focus): 7
Are the conclusions adequately supported by the data presented?: Yes
Are any compounds reported adequately characterized?: Yes

Reviewer: 2
Recommendation: Publish as is; no revisions needed.
Comments:This manuscript described a practical method to synthsize hydrazide-activated polymer microparticles and its application to immobilize carbohydrate. The synthesis is clearly described and should find plenty of applications in biomedical research; therefore, it should be accepted by Biomacromolecules. Further applications of this method and the resulting materials should be looked into carefully to solve important problems in biomedical research.
Please rate the overall importance of this manuscript to the field of biomacromolecules (10 �High Importance/ 1 �Low Importance): 7
Please rate the element of novelty in the research reported (10 - High Novelty / 1 - Low Novelty): 5
Please rate the interest to scientists working in the field of biomacromolecules (10 - High Interest / 1 - Low Interest): 8
Please rate the focus of the manuscript on the interface of polymer science and the biological sciences (10 - High Focus / 1 - Low Focus): 8
Are the conclusions adequately supported by the data presented?: Yes
Are any compounds reported adequately characterized?: Yes
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