| ²é¿´: 1169 | »Ø¸´: 0 | |||
lantern28гæ (СÓÐÃûÆø)
|
[½»Á÷]
Ìì½òÒ½¿Æ´óѧ/ʵÑéѪҺѧ¹ú¼ÒÖØµãʵÑéÊÒºúµÂÇì¿ÎÌâ×éÕÐÆ¸½²Ê¦/¸±½ÌÊںͲ©Ê¿ºó
|
|
ºúµÂÇ죬Ìì½òÒ½¿Æ´óѧ»ù´¡Ò½Ñ§Ôº½ÌÊÚ£¬Ìì½òÊÐҽѧ±í¹ÛÒÅ´«Ñ§ÖصãʵÑéÊÒºÍÖйúҽѧ¿ÆÑ§ÔºÑªÒº²¡Ò½ÔºÊµÑéѪҺѧ¹ú¼ÒÖØµãʵÑéÊÒPI£¬ ²©Ê¿Éúµ¼Ê¦¡£2010Ä격ʿ±ÏÒµÓÚÖйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù£¬Ö®ºóÔÚÃÀ¹úÎ÷±±´óѧ£¨Northwestern University£©ºÍÃÀ¹ú˹ÍÐÍß˹ҽѧÑо¿Ëù£¨Stowers Institute for Medical Research£©µÄAli ShilatifardÓëLinheng Li £¨ÀîÁèºâ£© ʵÑéÊÒ½øÐв©Ê¿ºóÑо¿£¬Íê³ÉÔÚ±í¹ÛÒÅ´«Ñ§ºÍ¸Éϸ°ûÉúÎïѧÁ½¸öÁìÓòµÄרҵѵÁ·¡£Ä¿Ç°ÒÔµÚÒ»×÷Õß»òͨѶ×÷ÕßÔÚMolecular Cell (2013, 2017), Nature Structure &Molecular Biology, Genes &Development, Science AdvancesµÈÔÓÖ¾·¢±í¶àƪÑо¿ÂÛÎÄ£¬×ÜÒýÓÃ1700Óà´Î£¬5ÄêÄÚµ¥Æª×î¸ßÒýÓÃ240Óà´Î£¬HÖ¸Êý19¡£³¤ÆÚÖÂÁ¦ÓÚ±í¹ÛÒÅ´«Ñ§Óë»ùÒòת¼µ÷¿ØµÄ·Ö×Ó»úÖÆÑо¿£¬Ö÷ҪѧÊõ³É¼¨°üÀ¨£º1. ·ÖÀë¼ø¶¨Á˲¸È鶯ÎïµÄLEC (Little Elongation Complex)¸´ºÏÌå (Molecular Cell, 2013)£»2.¼ø¶¨ÁËMLL2/COMPASS¸´ºÏÌ彨Á¢bivalentȾɫÖÊÐÞÊεÄÉú»¯»úÖÆ (Nat Struct Mol Biol, 2013)£»3.¼ø¶¨ÁËMLL3/MLL4/COMPASS¸´ºÏÌ彨Á¢×ªÂ¼ÔöÇ¿×Ó±í¹ÛÒÅ´«Ñ§±ê¼Ç-H3K4me1µÄ·Ö×Ó»úÖÆ (MCB, 2014)£»4. ·¢ÏÖ»îԾת¼ÔöÇ¿×ÓµÄÐÂÐͱí¹ÛÒÅ´«Ñ§±ê¼Ç¼°Æä½¨Á¢µÄÉú»¯»úÖÆÒÔ¼°ÔÚµ÷¿ØÔçÆÚÅßÌ¥·¢ÓýÖеŦÄÜ (Molecular Cell, 2017)£»5.·¢ÏÖת¼ÔÝÍ£/ÑÓÉìºÍ±í¹ÛÒÅ´«ÐÞÊÎÔÚLEDGF/p75µ÷¿ØHIVDZ·ü¸ÐȾÓë¸´ÖÆÖеŦÄÜÓë×÷ÓûúÖÆ (Science Advances, 2020)¡£ Ŀǰ¿ÎÌâ×éÖ÷Òª´Óʱí¹ÛÒÅ´«Ñ§ºÍ»ùÒòת¼µ÷¿Ø»úÖÆÑо¿¡£ÊµÑéÊÒ¾¹ý½ü2ÄêµÄ·¢Õ¹£¬ÒѾ½¨Á¢ÁËÍ걸µÄ»ùÒòת¼µ÷¿ØºÍ±í¹ÛÒÅ´«Ñ§¼¼Êõƽ̨ÓëʵÑéÌåϵ¡£ÏÖÒò¿ÎÌâÑо¿ÐèÒª£¬³ÏƸÒÔÏÂÈËÔ±£º Ò»£®½²Ê¦/¸±½ÌÊÚ1-2Ãû ¸ÚλְÔ𣺠1. ÔÚPIµÄÖ¸µ¼Ï£¬¶ÀÁ¢¿ªÕ¹ÊµÑéÊÒÏà¹Ø¿ÎÌâÑо¿£¬×«Ð´É걨¿ÆÑлù½ð¡£ 2. ÐÖúPI¿ªÕ¹½Ìѧ¡¢¿ÆÑм°ÊµÑéÊÒÑо¿ÉúÅàÑø¹¤×÷¡£ ӦƸҪÇó£º 1£® ÒÑ»ñµÃ»ò½üÆÚ¼´½«»ñµÃÉúÎﻯѧ/·Ö×ÓÉúÎïѧ/ϸ°ûÉúÎïѧ/ÉúÎïÐÅϢѧ/ѪҺѧ/ÃâÒßѧÏà¹Ø×¨ÒµµÄ²©Ê¿Ñ§Î»¡£ 2£® ÓпÆÑÐÈÈÇ飬ÔðÈÎÐÄÇ¿£¬¾ßÓÐÁ¼ºÃµÄÍŶӺÏ×÷¾«ÉñºÍ¿ÆÑÐ×éÖ¯ÄÜÁ¦¡£ 3£® ÒÔµÚÒ»×÷ÕßÔÚ¹ú¼ÊÖªÃûѧÊõÆÚ¿¯ÉÏ·¢±í¹ýѧÊõÂÛÎÄ¡£ 4£® ¾ß±¸½ÏÇ¿µÄÓ¢ÎÄд×÷Óë½»Á÷ÄÜÁ¦¡£ 5£® ÉíÐĽ¡¿µ¡¢¹¤×÷ÈÏÕæÏ¸Ö£¬ÑϽ÷Çóʵ£¬ÌõÀíÐÔÇ¿¡£ ¶þ£®²©Ê¿ºó2-4Ãû£º ¸ÚλְÔ𣺠1. ÔÚPIÖ¸µ¼Ï£¬¶ÀÁ¢¿ªÕ¹¿ÆÑÐÏîÄ¿¡£ 2. ²ÎÓë¿ÆÑлù½ðÉêÇë¡£ ӦƸҪÇó£º 1. ¾ßÓÐÉúÎﻯѧ/·Ö×ÓÉúÎïѧ/ϸ°ûÉúÎïѧ/ѪҺѧ/ÉúÎïÐÅϢѧ/ÃâÒßѧÏà¹Ø×¨ÒµµÄ²©Ê¿Ñ§Î»¡£ 2. ÓпÆÑÐÈÈÇ飬ɯÓÚ˼¿¼£¬Äܹ»¶ÀÁ¢Íê³ÉPI½»´úµÄ¿ÎÌâÑо¿¡£ 3. ¾ß±¸½ÏÇ¿µÄÓ¢ÎÄд×÷Óë½»Á÷ÄÜÁ¦¡£ 4. ÒÔµÚÒ»×÷ÕßÔÚÔÚ¹ú¼ÊÖªÃûѧÊõÆÚ¿¯ÉÏ·¢±í¹ýSCIÂÛÎÄ¡£ 5. ÉíÐĽ¡¿µ¡¢¹¤×÷ÈÏÕæÏ¸Ö£¬ÑϽ÷Çóʵ£¬ÌõÀíÐÔÇ¿¡£ ¸Úλ´ýÓö£º ½²Ê¦/¸±½ÌÊÚְλ´ýÓö°´ÕÕÌì½òÊкÍÌì½òÒ½¿Æ´óѧÏà¹ØÕþ²ßÖ´ÐС£ ²©Ê¿ºó¸Úλ´ýÓöÈçÏ£º 1. ÌṩÁ¼ºÃµÄ¹¤×÷Ìõ¼þ¡¢¹æ·¶µÄ¿ÆÑÐÅàѵºÍ³ä×ãµÄÑо¿¾·Ñ¡£ 2. ²©Ê¿ºó¿ÉÒÔÑ¡Ôñ´ÓÌì½òÒ½¿Æ´óѧ»òÖйúҽѧ¿ÆÑ§ÔºÊµÑéѪҺѧ¹ú¼ÒÖØµãʵÑéÊÒ½øÕ¾¡£ 3. ½øÕ¾ºó£¬¸ù¾ÝÌì½òÊÐÏà¹ØÕþ²ß¸øÓèÒ»´ÎÐÔÉú»î²¹Ìù5ÍòÔªÈËÃñ±Ò¡£ 4. ÔÚÕ¾ÆÚ¼ä²ÎÕÕÌì½òÒ½¿Æ´óѧÐÂÆ¸½²Ê¦±ê×¼¶ÒÏÖ´ýÓö£¬Í¬Ê±ÏíÊܱ¾µ¥Î»Ö°¹¤Í¬µÈµÄÉç»á±£ÏÕ¡£¹¤×÷³É¼¨Í»³öÕߣ¬¿ÉÉ걨¡°Ìì½òÒ½¿Æ´óѧ²©Ê¿ºó¼¤Àø¼Æ»®¡±£¬ÈëÑ¡ºó»ù´¡Ð½³êΪ˰ǰ20ÍòÔªÈËÃñ±Ò/Ä꣨°üÀ¨Ñ§Ð£ÌṩµÄ¹«»ý½ð£©¡£ÔÚÕ¾ÆÚ¼äÈç¹û»ñµÃ¹ú¼Ò¼¶ÏîÄ¿»òÒÔµÚÒ»×÷ÕßÉí·Ý·¢±íSCIÎÄÕ£¨IF>5£©£¬¸øÓè½±Àø¼¨Ð§5ÍòÔªÈËÃñ±Ò/Äê¡£ÈëÑ¡¹ú¼Ò²©Ê¿ºó´´ÐÂÈ˲ÅÖ§³Ö¼Æ»®Õߣ¬ÔÚ¡°²©Ð¼ƻ®¡±Ö´ÐÐÆÚÄÚ£¬×î¸ß¿ÉÏíÊÜ˰ǰÄêн35ÍòÈËÃñ±Ò¡£ 5. ʵÐС°2+X¡±ÅàÑøÄ£Ê½¡£ÔÚÕ¾ÆÚÂú2Äêºó£¬½øÐп¼ºË£»¿¼ºËÓÅÐãÕߣ¬¿É¼ÌÐøÔÚÕ¾¹¤×÷2-4Äê¡£ 6. ²©Ê¿ºóÑо¿ÈËÔ±¿ÉÏíÊÜѧУµÄ²©Ê¿ºó¹«Ô¢£¬»òÕß×â·¿²¹Ìù¡£ 7. ÓÅÐãÕ߯¸ÆÚÄÚ¿Éͨ¹ýѧУ¸±½ÌÊÚÕÐÆ¸³ÌÐòÉ걨ÏàÓ¦¸Úλ£¬Í¬µÈÌõ¼þÏÂÓÅÏȼȡ¡£ ÇëÓÐÒâÇÒ·ûºÏÌõ¼þÕß½«¼òÀú·¢ËÍÖÁhudq@tmu.edu.cn¡£Óʼþ±êÌâӦעÃ÷¡°Ó¦Æ¸¸Úλ+²©Ê¿±ÏҵԺУ+ÄâÈëְʱ¼ä¡±£¬ºÏÊÊÕß½«½üÆÚ°²ÅÅÃæÊÔ¡£ |
» ²ÂÄãϲ»¶
285Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
ÉúÎïѧÇóµ÷¼Á
ÒѾÓÐ4È˻ظ´
0854Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
319·Ö085702°²È«¹¤³ÌÇóµ÷¼Á
ÒѾÓÐ4È˻ظ´
ÉúÎïѧ308·ÖÇóµ÷¼Á£¨Ò»Ö¾Ô¸»ª¶«Ê¦´ó£©
ÒѾÓÐ6È˻ظ´
085600²ÄÁÏÓ뻯¹¤301·ÖÇóµ÷¼ÁԺУ
ÒѾÓÐ14È˻ظ´
0703»¯Ñ§µ÷¼Á325·Ö
ÒѾÓÐ12È˻ظ´
ÇóÖú071001µ÷¼Á£¡£¡£¡
ÒѾÓÐ5È˻ظ´
¹¤¿Æ370Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
²ÄÁÏר˶322
ÒѾÓÐ10È˻ظ´














»Ø¸´´ËÂ¥