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1. Combine Histograms in Figure 1 and differentiate using different /greyscale and shading etc
2. Combine Histograms in Figure 2 and differentiate using different /greyscale and shading etc
3.  Figures 3 B and C will be unreadable in a journal format so move to Supplementary and perhaps present the aspects of the data.
4.  Figures 4 B to figure I should be re-formatted into a more viewable format.  The graphs provided are not effective.
5.  Figures 5 A through to H  are inefficient with redundancy in the figures and are not suitable for journal format.  Please reformat the figures.

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