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求助 一小段英文摘要翻译！（10金币奉上）
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标题：The co-administration of CpG-ODN influenced protective activity of influenza M2e Vaccine. 摘要：In this report, we investigated the adjuvant effect of CpG-ODN on the immunogenicity and protective efficacy of influenza M2e peptide vaccine. We found that the addition of CpG-ODN 1826 into aluminum-adjuvant M2e peptide vaccine increased M2e-specific Th1 immune response, indicated by higher titers of M2e-specific IgG2a and more IFN-gamma-secreting lymphocytes. However, according to the result from virus challenge, enhancement of M2e-specific Th1 immune response failed to increase the protection against influenza virus. Moreover, when challenged with high dose of influenza virus, the addition of CpG-ODN even weakened the protective activity. These results suggested that the intensity of immune responses was not simply correlated with protective activity of influenza M2e vaccine and more comprehensive criterion should be built up for the evaluation of M2e-based vaccine. |
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2楼2009-07-04 09:33:17
3楼2009-07-04 10:14:23
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braynt24(金币+10,VIP+0):谢谢！！！ 7-4 20:33
braynt24(金币+10,VIP+0):谢谢！！！ 7-4 20:33
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受CpG-ODN共同作用影响的流感M2e疫苗的保护作用 在本报告中，我们研究了CpG-ODN 对流感M2e肽疫苗的免疫原性和保护效力的辅助作用。我们发现M2e特有的IgG2a有更高的滴定量，且分泌伽马干扰素的淋巴细胞也增多，说明在铝佐M2e肽疫苗中添加CpG-ODN 1826能够增加M2e特有的Th1 免疫应答。然而从病毒攻击的结果来看，M2e特有的Th1免疫应答的增强没有增强对流感病毒的防御作用。而且当攻击高剂量的流感病毒时，CpG-ODN 的添加甚至会减弱保护作用。这些结果表明免疫应答的程度与流感M2e疫苗之间并不是简单的关系，流感M2e疫苗的评估还需要建立更加综合的评价标准 |
4楼2009-07-04 11:55:02