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虫号: 21358857

[交流] 香港中文大学（深圳）诚聘【实验室工程师/高级实验室工程师】

具体工作地点:

深圳市龙岗区龙翔大道2001号香港中文大学（深圳）

薪金:

面谈

学历和研究方向:

生物化学

招聘岗位:

实验室工程师

公司名称:

香港中文大学（深圳）

公司网址:

https://www.cuhk.edu.cn/zh-hans/jobs?jid=234

联系方式:

liuzheng@cuhk.edu.cn

香港中文大学（深圳）诚聘【实验室工程师/高级实验室工程师】

【岗位要求】
•结构生物学，生物化学，生物物理学，材料科学或相关领域的博士，有经验的硕士也将考虑
•2-3年的cryo-EM经验，包括处理样品，使用显微镜和图像评估
•了解透射电子显微镜和3D结构确定的原理
•对cryo-EM工作流程的有一般了解
•乐于学习新技术并应对新挑战
•愿意参加开发/测试新方法/技术
•团队协作能力，沟通能力强

【工作职责】
•帮助维护和操作冷冻电子显微镜如Titan Krios及相关设备
•帮助定期进行电镜流程测试并优化电镜性能以进行数据收集
•参与冷冻电镜的方法开发/优化
•与具有不同经验水平的用户互动/对其进行培训
•维护设施日常运行记录

【申请程序】
请准备好完整的中、英文简历，申请表（此网页下载）发送至邮箱：liuzheng@cuhk.edu.cn

【简介】
科比尔卡创新药物开发研究院（KIIDD）是香港中文大学（深圳）组建的首批诺贝尔奖科学家实验室之一。研究院的重点研究领域集中在新药开发上，研究方向主要包括药物受体结构生物学研究、药物计算化学研究、功能药物分子的有机合成和药物化学的研究、受体功能药物分子的功能药理学等。通过X射线单晶衍射、核磁共振和冷冻电子显微学等方法进行药物受体结构生物学研究，借助计算机辅助和分子模拟进行药物设计，对功能药物分子合成和药物化学、药理学原理进行研究，进行对新型药物进行合成制备，为今后的临床研究提供药理学理论支撑。

本次招聘的岗位隶属于香港中文大学（深圳）科比尔卡冷冻电子显微中心，它是KIIDD在深圳市龙岗区政府的大力支持下，历时一年打造的高性能冷冻电子显微平台，也是龙岗区第一个结构生物学平台。中心致力于建设成具有国际一流核心技术和分析能力的高端科研平台，与世界顶尖高校开展深度合作与交流，推动研究院产学研创新和突破，开展龙岗区和深圳在相关领域的产业化和项目转化。

科比尔卡冷冻电子显微中心是以提供有偿服务的设施为基础，由工作人员使用冷冻电镜成像，来辅助科研人员进行科学研究，为研究院的发展提供专业的支持与优良的平台。中心与科研人员紧密合作，确定最佳的实验设计方案，包括样品制备策略，维护和操作低温电子显微镜以及辅助设备以提供高分辨率图像，以及在数据管理和分析方面提供指导和服务。

~~~~~~~~~~~~~~~~~~~~~~~~~~分界线~~~~~~~~~~~~~

【Preferred Qualifications】
•M.S in structural biology, biophysics, biochemistry, material science or related field, Ph.D would be a plus
•2-3 years of experience in cryo-EM including handling samples, using microscopes and evaluation of images
•Knowledge of the principles of transmission electron microscopy and 3D structure determination
•General understanding of cryo-EM workflow
•Excellent communication and interpersonal skills
•Motivated to learn new technologies and to take on new challenges
•Willing to develop/test new methods/techniques
•Excellent organizational skills and record keeping
•Special consideration will be given to candidates with a record of achievement in collaborative, team-driven environments

【Responsibilities】
•Help maintain and operate cryo electron microscopes and related equipment
•Regularly benchmark and optimize microscope performance for data collection
•Participate in method developments/optimization for cryo-EM
Interact closely with/train users with different levels of experience
•Maintain record of daily operations in the facility

【Application Procedure】
Please send a full curriculum vitae and the completed Application Form (please download the template online) by email to liuzheng@cuhk.edu.cn

【Brief Introduction】
Kobilka Institute of Innovative Drug Discovery is one of the first batch of Nobel laureate labs at the University. Led by Prof. Brian K. Kobilka, the Nobel laureate in Chemistry in 2012, the Kobilka Institute of Innovative Drug Discovery (KIIDD) is a significant milestone in the University’s attempt to evolve into a world research university.

KIIDD will focus on new drug development which includes drugs receptor structural biology research, computational chemistry research, the function of the drug molecules in organic synthesis and medicinal chemistry research, receptor function the function of the drug molecule pharmacology, etc. Researchers in KIIDD are going to carry out studies about the structural biology of drug receptors through lots of modern biological techniques, such as single crystal x-ray diffraction, Nuclear magnetic resonance (NMR) and electron microscopy. CAD and molecular simulations were used in the drug designs. KIIDD lay eyes on functional drug synthesis, medicinal chemistry and pharmacology, to further explore the pathways to make new drugs, as well as offering intellectual support on pharmacology for future clinical research.

The Kobilka Cryo-EM center is a fee-for-service facility operated by the KIIDD at Chinese University of Hongkong(Shenzhen) as a state-of-the-art shared resource for biomedical researchers. The Cryo-EM staff members develop and provide their knowledge and expertise to the research community at KIIDD in applying cryo-EM imaging to their research. They work closely with investigators to define optimal experimental design including strategies for preparation of samples, maintain and operate cryo-electron microscopes and ancillary equipment in order to provide high resolution images, and provide guidance and service in data management and analysis.

The successful candidate will assist facility staff with maintenance and operation of the advanced instrumentation housed in the Cryo-EM core and will work with and train users in specimen preparation. The candidate will also be responsible for record keeping associated with users, instrument logs, and routine operation of the facility. The candidate will be expected to learn new procedures as they are developed and implemented by the facility.

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