| 查看: 436 | 回复: 0 | |||
[交流]
过敏性鼻炎儿童舌下免疫治疗后IL-33表达水平下降
|
|
Objectives： To identify the expression of IL-33 during SLIT (Sublingual immunotherapy) in AR (Allergic rhinitis) children. Methods：Thirty children received house dust mite (HDM) allergen extract for SLIT and thirty children received placebo in this study. Serum and nasal lavage samples of cases and controls were collected at different time points during SLIT. Interleukin (IL)-33 and other cytokines were estimated in these samples by enzyme-linked immuno sorbent assay (ELISA). Peripheral blood mononuclear cells (PBMC) were prepared and stimulated with rhIL-33 (with or without other stimulators) at different time points during SLIT. Results： The present results showed that both serumand nasal lavage of IL-33 levels decreased significantly after 12 mo treatment and this trend maintained at least until 24 mo. The decreased nasal IL-33 level was positively correlated to local Th2 cytokines and increased IL-10 expression at 2 y post SLIT treatment. In vitro experiments showed that IL-33 promotes IL-4 and IL-5 and inhibits IL-10 expression by peripheral blood mononuclear cells (PBMCs) in AR. Conclusions： Decreased IL-33 expression during SLIT may contribute to low Th2 response and enhanced Regulatory T cell cytokines expression. Thus, IL-33 maybe an important predictor during SLIT. |
回复此楼» 猜你喜欢
这两条意见是什么意思？
已经有2人回复
-
Image J软件计算薄膜颜色L*a*b*值
已经有2人回复
-
法医学论文润色/翻译怎么收费?
已经有221人回复
-
求助，中药天然产物大全:中药.11,下篇4536-8979， 第7355页，谢谢
已经有0人回复
-
哪位大佬写过神经介入方面的文章
已经有9人回复
-
请问有斯坦福那边的朋友吗
已经有0人回复
-
投稿求助
已经有0人回复
-
生物化学与分子生物学的抑癌基因部分！
已经有0人回复
-
case report 投稿期刊选择求助
已经有2人回复
-
国自然计划书状态还是“等待基金委接收纸质”
已经有15人回复