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ranscriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques
By Michael Carey, Stephen T. Smale
Publisher: Cold Spring Harbor Laboratory Press
Number Of Pages: 640
Publication Date: 2000-01-15
ISBN-10 / ASIN: 0879695374
ISBN-13 / EAN: 9780879695378
Binding: Hardcover
In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor.
Chapter 1 reviews the state-of-the-art in the RNA polymerase II transcription field;
Chapters 2â “10 are a systematic guide to the investigation of regulatory mechanisms for newly identified genes;
Chapters 11â “15 discuss approaches for synthesizing recombinant transcription factors, analyzing their binding, and deciphering their mode of action.
Transcriptional Regulation in Eukaryotes reveals not only what to do but why, and how to plan properly for success. This approach is ideal for graduate students, physician-scientists, postdocs, and others entering the field, but is also valuable for established investigators undertaking in-depth studies in specific systems.
Summary: a great reference for transcription lab work!
Rating: 5
I purchased this book for my lab and I cannot praise it highly enough. The only problem is that grad students and postdocs keep stealing it from my office and I'm always having to go out and hunt it down on someone's bench! When introducing a new technique to your lab, it is a good idea to read the chapater on that technique before you pick up your pipet. The descriptions of methodology and the degree of detail are first rate. I hope that Carey and Smale bring out a new edition soon that covers the new innovations in the transcription field from the five years since their current edition was published.
Lori Bernstein
Assistant Professor
Texas A & M University
Summary: Good Book for the beginner and expert....
Rating: 4
There are so many method for experiment regarding transcriptional regulations. In this book, you may find brief purpose, background knowledge and technical guide for the allmost experiment about transcriptional regulations.
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