| 查看: 2676 | 回复: 6 | ||
| 【奖励】 本帖被评价6次，作者尘3687增加金币 4.8 个 | ||
[资源]
Polymorphism in the Pharmaceutical Industry （2018）
|
||
|
Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development（制药行业中的多态性：固体形式和药物开发 2018版） About this book "Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry. 目录 CHAPTER 1 Solid State and Polymorphism of the Drug Substance in the Context of Quality by Design and ICH Guidelines Q8–Q12 (Pages: 1-30) CHAPTER 2 Alternative Solid Forms: Salts (Pages: 31-59) CHAPTER 3 Alternative Solid Forms: Co‐crystals (Pages: 61-90) CHAPTER 4 Thermodynamics of Polymorphs and Solvates (Pages: 91-132) CHAPTER 5 Toward Computational Polymorph Prediction (Pages: 133-157) CHAPTER 6 Hygroscopicity and Hydrates in Pharmaceutical Solids (Pages: 159-188) CHAPTER 7 The Amorphous State (Pages: 189-239) CHAPTER 8 Approaches to Solid‐Form Screening (Pages: 241-259) CHAPTER 9 Nucleation (Pages: 261-283) CHAPTER 10 Crystallization Process Modeling (Pages: 285-304) CHAPTER 11 Crystallization Process Scale‐Up, a Quality by Design (QbD) Perspective (Pages: 305-328) CHAPTER 12 Processing‐Induced Phase Transformations and Their Implications on Pharmaceutical Product Quality (Pages: 329-380) CHAPTER 13 Surface and Mechanical Properties of Molecular Crystals (Pages: 381-414) CHAPTER 14 Analytical Tools to Characterize Solid Forms (Pages: 415-446) CHAPTER 15 Industry Case Studies (Pages: 447-468) CHAPTER 16 Pharmaceutical Crystal Forms and Crystal‐Form Patents: Novelty and Obviousness |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : polymorphism-in-the-pharmaceutical-industry-2018.pdf
2020-01-08 14:09:42, 14.08 M
» 猜你喜欢
河北省自然科学基金
已经有8人回复
-
西安交大新媒学院副院长用撤稿论文结题
已经有5人回复
-
论文撤稿了
已经有5人回复
-
某211大学教师把个人教师官方主页改成:我跑了我跑了我跑了!官宣跑路！
已经有5人回复
-
26/27申博自荐
已经有9人回复
-
售SCI一区T0P文章，我:8.O.5.5.1.O.5.4,科目齐全,可+急
已经有3人回复
-
售SCI一区T0P文章，我:8.O.5.5.1.O.5.4,科目齐全,可+急
已经有7人回复
-
揭秘青基评审内幕：几个A才能顺利中标
已经有4人回复
-
青B发送上会通知了吗
已经有7人回复
-
博士申请
已经有3人回复
5楼2020-07-01 20:34:35
简单回复
sjshvdc2楼
2020-01-09 12:25
回复
五星好评 顶一下，感谢分享！
yyykey3楼
2020-02-12 13:59
回复
五星好评 顶一下，感谢分享！
2020-02-13 16:29
回复
五星好评 顶一下，感谢分享！
刘欢欢爱学习6楼
2023-07-10 15:31
回复
五星好评 顶一下，感谢分享！
2024-02-15 10:34
回复
五星好评 顶一下，感谢分享！
10