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Table of contents 1. The First Twenty-Five Years of p53 Research Harlan Robins, Gabriela Alexe, Sandra Harris, A. J. Levine 2. Regulation of p53 DNA Binding Kristine McKinney, Carol Prives 3. 20 Years of DNA Damage Signaling to p53 Kevin G. McLure, Michael B. Kastan 4. Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel, Mark Wade 5. Regulation of the p53 Response by Cellular Growth and Survival Factors Lauren Brown, Samuel Benchimol 6. P53, Cell Cycle Arrest and Apoptosis Shulin Wang, Wafik S. El-Deiry 7. P53 Has a Direct Pro-apoptotic Action at the Mitochondria Ute M. Moll 8. Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor Lawrence A. Donehower, Dora Bocangel, Melissa Dumble, Guillermina Lozano 9. P53, P63, and P73: Internecine Relations? Frank McKeon, Annie Yang 10. P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells Olimpia Monti, Alexander Damalas, Sabrina Strano, Giovanni Blandino 11. P53: Gatekeeper, Caretaker or Both? Carlos P. Rubbi, Jo Milner 12. Analysis of p53 Gene Alterations in Cancer: A Critical View Thierry Soussi 13. Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection Hong Shi, Florence Calvez, Magali Olivier, Pierre Hainaut 14. Prognostic and Predictive Value of TP53 Mutations in Human Cancer Magali Olivier, Pierre Hainaut, Anne-Lise Børresen-Dale 15. P53 Links Tumor Development to Cancer Therapy Michael T. Hemann, Scott W. Lowe 16. Novel p53-Based Therapies: Strategies and Future Prospects Sonia Lain, David Lane 17. Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue Andreas C. Joerger, Assaf Friedler, Alan R. Fersht 18. Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy Galina Selivanova, Vladimir J. N. Bykov, Klas G. Wiman 19. Novel Approaches to p53-Based Therapy: ONYX-015 Frank McCormick 20. p53 as Seen by an Outsider George Klein ÏÂÔØÁ´½Ó£º http://www.namipan.com/d/25%20Ye ... 54efd771fdc4a920801 [ Last edited by zhoukoulk on 2009-6-14 at 19:27 ]

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