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金虫 (小有名气)

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专业: 合成药物化学

[交流] [Postdoc] cancer immunology and host-microbiome interaction 宾大博后招生已有1人参与

Postdoc Advertisement 博士后招生，欢迎大家联系

The Jin laboratory at the Perelman School of Medicine, University of Pennsylvania is recruiting multiple postdocs with diverse backgrounds and expertise to work at the forefront of cancer immunology and host-microbiome interaction.

Please visit our lab website (https://www.ccjinlab.com/) for detailed information!

About the PI:

Dr. Chengcheng Jin graduated from Tsinghua University with B.S. in Biological Sciences in 2007. She obtained her Ph.D. from Yale University, where she worked in the laboratory of Dr. Richard Flavell to study innate immune receptors in metabolic and tissue homeostasis. Then she joined Dr. Tyler Jacks’ laboratory at MIT to investigate microbiota-immune interaction in the tumor microenvironment. Her most recent work demonstrated the critical role of microbiota-immune crosstalk in promoting inflammation and tumor progression in lung cancer. Over the past twelve years of her doctoral and postdoctoral studies, Dr. Jin has developed a strong research program elucidating the mechanisms by which the immune system
senses diverse endogenous or exogenous signals to regulate various physiological or pathological processes. She has published a number of first or co-first author research articles in top journals including Cell, Science, Nature as well as review papers. Dr. Jin has also been recognized by many awards, including the NIH Pathway to Independence Award (K99/R00), the Helen Hay Whitney postdoctoral fellowship and the DOD Lung Cancer Research Concept Award.

Dr. Jin will join the Perelman School of Medicine at the University of Pennsylvania as a tenure-track
Assistant Professor starting January 2020. Her laboratory will be affiliated with the Department of Cancer
Biology, the Institute for Immunology and the Penn-CHOP Microbiome Program.

Research Areas:

The pathogenesis of cancer involves not only intrinsic genetic alterations in tumor cells but also the failure of immune surveillance and unresolved inflammation. However, it is not well understood how host-intrinsic or environmental factors direct the immune response towards tumor-promoting inflammation versus anti-tumor immunity during tumor progression. In particular, mucosal surfaces exposed to the external environment are colonized by a vast number of microbes, collectively referred to as the commensal microbiota. The work from us and others have just begun to unveil the critical role of commensal microbiome in shaping the tumor microenvironment (TME) to regulate the tumor-immune interactions. This is an area of tremendous opportunity for significant breakthroughs in cancer research.

The Jin lab will explore the fascinating interplay between the host immune system, commensal microbiota and developing tumor cells in cancer development and treatment, using a combination of genetically engineered mouse models and state-of-the art technologies including multi-omics, advanced imaging, and CRIPSR/cas9 based gene editing tools. Specifically, the Jin lab will be at the forefront of:
(1) Understanding how immune responses initiate and evolve over time as tumors arise de novo and
progress;
(2) Defining the molecular and cellular mechanisms by which the immune system senses and
responds to microbiota-derived or tumor-intrinsic signals in the TME to regulate tumor growth and cancer
responses to therapies.

Postdoc positions:

The Jin lab is looking for highly motivated and talented scientists to join our team and address the fundamental questions in cancer immunology and mucosal immune-microbiota interaction. Candidates with Ph.D., M.D., or equivalent degrees who are broadly interested in cancer biology, immunology, microbiology, mouse genetics, bioinformatics or related areas are welcome to apply!

Please email your CV, a brief description of your previous work and your future research interests and contact information for three references to be sent to ccjin@mit.edu or jinlab.upenn@gmail.com if interested.

Complete publication list of Dr. Jin:
https://www.ncbi.nlm.nih.gov/myn ... ibliography/public/

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