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In human HeLa cells, the let-7 miRNA inhibits the initiation of translation of a reporter construct bearing MREs for let-7 in its 3＇UTR and leads to sequestration of the repressed mRNA in processing bodies (PBs) in a cap-dependent manner (Pillai et al., 2005). PBs are cytoplasmic bodies enriched in mRNA decay enzymes, where translationally repressed mRNAs are localized (Sheth and Parker, 2003). 发自小木虫Android客户端 |
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