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dentist_fuyf金虫 (小有名气)
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| Zhi Yang, Hao Gu, Gang Sha, et al. TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro[J]. ACS Applied Materials& Interfaces 2018, 10:41155−41166 |
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入藏号: WOS:000452694100023 TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro 作者:Yang, Z (Yang, Zhi)[ 1,2,3 ] ; Gu, H (Gu, Hao)[ 1,2,3 ] ; Sha, G (Sha, Gang)[ 4 ] ; Lu, WJ (Lu, Weijie)[ 5 ] ; Yu, WA (Yu, Weigiang)[ 1,2,3 ] ; Zhang, WJ (Zhang, Wenjie)[ 1,2,3 ] ; Fu, YF (Fu, Yuanfei)[ 1,2,3 ] ; Wang, KS (Wang, Kuaishe)[ 6 ] ; Wang, LQ (Wang, Liqiang)[ 5 ] 查看 Web of Science ResearcherID 和 ORCID ACS APPLIED MATERIALS & INTERFACES 卷: 10 期: 48 页: 41155-41166 DOI: 10.1021/acsami.8b16343 出版年: DEC 5 2018 文献类型:Article 查看期刊影响力 摘要 Numerous antibacterial biomaterials have been developed, but a majority of them suffer from poor biocompatibility. With the purpose of reducing biomaterial-related infection and cytotoxicity, friction stir processing (FSP) was employed to embed silver nanoparticles (Ag NPs) in a Ti- 6A1-4V (TC4) substrate. Characterization using scanning electron microscopy, transmission electron microscopy, and three-dimensional atom probe tomography illustrates that NPs are distributed more homogeneously on the surface of TC4 as the groove depth increases, and silver-rich NPs with a size from 10 to 20 nm exist as metallic silver diffused into the substrate, where the silver content is 4.3-5.6%. Electrochemical impedance spectroscopy shows that both FSP and the addition of silver have positive effects on corrosion resistance. The modified samples effectively inhibit both Staphylococcus aureus and Escherichia coli strains and slightly reduce their adhesion while not displaying any cytotoxicity to bone mesenchymal stem cells in vitro. The antibacterial effect is independent of Ag-ion release and is likely due to the number of embedded silver NPs on the surface, which directly contact and subsequently destroy the cell membrane. Our study shows that the TC4/Ag metal matrix nanocomposite is a potential infection-related biomaterial and that embedding Ag NPs tightly on a biomaterial surface is an effective strategy for striking a balance between the antibacterial effect and biocompatibility, providing an innovative approach for accurately controlling the cytotoxicity of infection-related biomaterials. 关键词 作者关键词:metal matrix nanocomposites; friction stir processing; surface characterization; antibacterial property; cytotoxicity KeyWords Plus:SILVER NANOPARTICLES; BIOLOGICAL-PROPERTIES; CORROSION BEHAVIOR; INFECTION; COATINGS; BIOFILM; TITANIA; RESISTANCE; CATHETERS; MECHANISM 作者信息 通讯作者地址: Fu, YF (通讯作者) 显示更多显示较少 Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Dept Prosthodont,Sch Med, Shanghai 200011, Peoples R China. 通讯作者地址: Fu, YF (通讯作者) Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China. 通讯作者地址: Fu, YF (通讯作者) Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China. 通讯作者地址: Wang, LQ (通讯作者) 显示更多显示较少 Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China. 通讯作者地址: Wang, KS (通讯作者) 显示更多显示较少 Xian Univ Architecture & Technol, Sch Met Engn, Xian 710055, Shaanxi, Peoples R China. 地址: 显示更多显示较少 [ 1 ] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Dept Prosthodont,Sch Med, Shanghai 200011, Peoples R China [ 2 ] Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China [ 3 ] Natl Clin Res Ctr Stomatol, Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China 显示更多显示较少 [ 4 ] Nanjing Univ Sci & Technol, Herbert Gleiter Inst Nanosci, Nanjing 210094, Jiangsu, Peoples R China 显示更多显示较少 [ 5 ] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China 显示更多显示较少 [ 6 ] Xian Univ Architecture & Technol, Sch Met Engn, Xian 710055, Shaanxi, Peoples R China 电子邮件地址:fuyuanf@163.com; wangkuaishe888@126.com; wang_liqiang@sjtu.edu.cn 基金资助致谢 基金资助机构 授权号 National Key R&D Program of China 2017YFC0840110 National Science Foundation 51831011 51674167 51504152 Medical Engineering Cross key Research Foundation of the Shanghai Jiao Tong University YG2017ZD06 查看基金资助信息 出版商 AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 期刊信息 Impact Factor (影响因子): Journal Citation Reports 类别 / 分类 研究方向:Science & Technology - Other Topics; Materials Science Web of Science 类别:Nanoscience & Nanotechnology; Materials Science, Multidisciplinary 文献信息 语言:English 入藏号: WOS:000452694100023 PubMed ID: 30403843 ISSN: 1944-8244 其他信息 IDS 号: HD6XR Web of Science 核心合集中的 "引用的参考文献": 67 Web of Science 核心合集中的 "被引频次": 1 |
3楼2019-05-16 14:28:30
