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jarm190(liouzhan654´ú·¢): ½ð±Ò+4, ¸Ðл½»Á÷ 2019-05-09 13:52:26
jarm190(liouzhan654´ú·¢): ½ð±Ò+4, ¸Ðл½»Á÷ 2019-05-09 13:52:26
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Accuracy of microRNAs for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis ×÷Õß:He, S (He, Song)[ 1 ] ; Hu, XW (Hu, Xiao-Wu)[ 1 ] ; Wang, D (Wang, Dong)[ 1 ] ; Han, LF (Han, Ling-Fei)[ 1 ] ; Zhang, DC (Zhang, De-Chun)[ 2 ] ; Wei, C (Wei, Cheng)[ 1 ] CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY ¾í: 40 ÆÚ: 4 Ò³: 405-417 DOI: 10.1016/j.clinre.2016.02.001 ³ö°æÄê: SEP 2016 ÎÄÏ×ÀàÐÍ:Review ²é¿´ÆÚ¿¯Ó°ÏìÁ¦ ÕªÒª Due to the high morbidity, mortality and late detection of hepatocellular carcinoma (HCC), it becomes a major public health challenge. MicroRNAs (miRNAs) have been reported to be aberrantly expressed in patients with HCC and thus may serve as potential diagnostic biomarkers. The aim of this study was to systematically assess the diagnostic accuracy of miRNAs as biomarkers for diagnosing HCC through a meta-analysis. Our results indicated that serum miRNAs had a relatively high diagnostic value for HCC diagnosis; the combination of serum 0:fetoprotein (AFP) and miRNAs displayed a better diagnostic accuracy than using AFP or miRNAs alone; the combination of multiple miRNAs assay in serum had the highest diagnostic accuracy in HCC diagnosis based on the published data. In conclusion, our meta-analysis suggests that miRNAs, especially serum miRNAs, had a relatively high diagnostic value for HCC diagnosis, which can discriminate HCC from healthy subjects and those with chronic hepatitis and cirrhosis easily, and may serve as a novel, less-invasive screening tool. (C) 2016 Elsevier Masson SAS. All rights reserved. ¹Ø¼ü´Ê KeyWords Plus OTENTIAL BIOMARKER; CANCER STATISTICS; CHRONIC HEPATITIS; PERFORMANCE; RISK×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: He, S (ͨѶ×÷Õß) Maanshan Municipal Hosp Grp, Maanshan Ctr, Clin Lab, 45 Hubei Rd, Maanshan 243000, Peoples R China. µØÖ·: [ 1 ] Maanshan Municipal Hosp Grp, Maanshan Ctr, Clin Lab, 45 Hubei Rd, Maanshan 243000, Peoples R China ÏÔʾ¸ü¶à [ 2 ] Chongqing Med Univ, Mol Med & Tumor Res Ctr, Chongqing 400016, Peoples R China µç×ÓÓʼþµØÖ·:jarm190@163.com »ù½ð×ÊÖúÖÂл »ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ Maanshan Municipal Public Health Bureau ²é¿´»ù½ð×ÊÖúÐÅÏ¢ ³ö°æÉÌ ELSEVIER MASSON, CORPORATION OFFICE, 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports Àà±ð / ·ÖÀà Ñо¿·½Ïò:Gastroenterology & Hepatology Web of Science Àà±ð:Gastroenterology & Hepatology ÎÄÏ×ÐÅÏ¢ ÓïÑÔ:English Èë²ØºÅ: WOS:000388875200013 PubMed ID: 27016891 ISSN: 2210-7401 eISSN: 2210-741X ÆäËûÐÅÏ¢ IDS ºÅ: ED5EU Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 44 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 7 |
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