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2Â¥2019-04-08 13:25:59
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vhhz(liouzhan654´ú·¢): ½ð±Ò+1, ¸Ðл½»Á÷ 2019-04-08 21:42:39
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ÄãÎÄÕÂÖк¬ÓжàͼµÄͼƬ(a, b, c, etc)£¬ÐèÒªÔÚͼƬ±êÌâÖн«Ã¿ÕÅСͼÃèÊöÇå³þ¡£ ±ÈÈç˵£º Fig. 4. ZF108-DNAJ1 transcriptionally activates mildly expressed proximal loci. (A) Browser track showing the ZF108-DNAJ1 ChIP-seq profile at FWA. The red arrow indicates the genomic location of the designed ZF108 target binding site. (B) Metaplot of expression change, centered on ZF108-DNAJ1 vs. random peaks. (C) Boxplot of expression changes for genes with promoters proximal to ZF108-DNAJ1 binding sites. n, number of genes. *P < 0.05 (Mann-Whitney test). (D) Observed over expected ratio for overlap of ZF108-DNAJ1 sites with up- or down-regulated ZF108-DNAJ1 gene promoters. (E) Boxplot of expression change for genes that overlap with ZF108- DNAJ1 peaks (upper panel), arranged by ascending WT expression decile (lower panel). Genes that lacked expression in both genotypes were removed. *P < 0.05 (Mann-Whitney test). ÒÔÉÏÄÚÈÝÀ´×Բο¼ÎÄÏ×£ºHarris et al., Science 362, 1182¨C1186 (2018) |
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