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ÊéÃû£ºChemical Genomics: Small Molecule Probes to Study Cellular Function
* Publisher:  Springer
    * Number Of Pages:  174
    * Publication Date:  2006-05-22
    * Sales Rank:  1397766
    * ISBN / ASIN:  3540278656
ÃèÊö£ºChemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
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1 Chemogenomics in Drug Discovery
H. Kubinyi . . . . . . . . . . . . . . . . . . . . . . . . . . 1
2 Chemogenomics Strategies
for G-Protein Coupled Receptor Hit Finding
W. Guba . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
3 Chemogenomics Approaches
to G-Protein Coupled Receptor Lead Finding
T. Klabunde, R. Jäger . . . . . . . . . . . . . . . . . . . . 31
4 Diversity Oriented Synthesis:
A Challenge for Synthetic Chemists
A. Bender, S. Fergus, W.R.J.D. Galloway, F.G. Glansdorp,
D.M. Marsden, R.L. Nicholson, R.J. Spandl, G.L. Thomas,
E.E. Wyatt, R.C. Glen, D.R. Spring . . . . . . . . . . . . . 47
5 Probing Protein Function with Small Molecules
J.D. Gough, C.M. Crews . . . . . . . . . . . . . . . . . . . 61
6 Tamoxifen-Based Probes for the Study
of Estrogen Receptor-Mediated Transcription
J.P. Trebley, E.L. Rickert, P.T. Reyes, R.V. Weatherman . . . 75
7 Protein Structure Similarity Clustering
and Natural Product Structure
as Guiding Principles for Chemical Genomics
M.A. Koch, H. Waldmann . . . . . . . . . . . . . . . . . . 89
X Contents
8 Tackling the Chemogenomic Space
by Novel Screening Technologies
L.M. Mayr . . . . . . . . . . . . . . . . . . . . . . . . . . 111
Previous Volumes Published in This Series . . . . . . . . . . . . 175
Èç¹ûϲ»µ½£¬¿ÉÁôÏÂÓÊÏ䣬±£Ö¤·¢µ½£¬²»ÒªÍüÁËÆÀ¼Û£¡:D
http://www.namipan.com/d/Jaroch_Chemical%20Genomics-Small%20Molecule%20Probes%20to%20Study%20Cellular%20Function.pdf/
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