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专业及方向:有机合成,肽合成, 注意: 不是分子生物学,是纯化学的 1- Chemical Synthesis of Proteins A) Manipulating Proteins with Chemistry B) Disulfide Bond Mimetics C) Glycopeptide and Glycoprotein Synthesis 2- Developing novel chemical approaches to control protein folding and self-assembly in health and disease 要求： 发送自己的CV到abrik@bgu.ac.il，可能会向你索要两封以上的推荐信。如果双方满意，可以立即前来开始工作。一般为两年，到期可以延长。 课题组简介： 课题组现在有7名成员，包括五名在读硕士博士和两名博士后，科研氛围良好，仪器设备齐全，有HPLC、LC-MS以及其他常用有机合成仪器，学校分析测试中心则具有大量现代分析仪器，课题组经费充足。 学校及系:以色列本古里安大学(www.bgu.ac.il)，Ben Gurion University of the Negev，化学系. 导师简介： Prof. Ashraf Brik，以色列犹太人，1973出生，英语极好,待人真诚,很好相处. 主页：http://www.ahlannet.com/sites/brik/index.php 2007-Current: Senior Lecturer (Assistant Professor), Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel. 2004-2006: Senior Research Associate, The Scripps Research Institute, La Jolla, California, (with professor Chi-Huey Wong). 2002-2004: Postdoctoral Associate, The Scripps Research Institute La Jolla, California, (with professor Chi-Huey Wong). 1998-2001: Ph.D. Technion-Israel Institute of Technology, Department of Chemistry, Haifa, Israel. Advisor: Professor Ehud Keinan, jointly with The Scripps Research Institute, La Jolla, California. Advisor: Professor Phillip Dawson. 1996-1998: M.Sc. Technion-Israel Institute of Technology, Department of Chemistry, Haifa, Israel. 1993-1996: B.Sc. Ben-Gurion University of the Negev, Department of Chemistry, Beer Sheva, Israel. 目前已经申请到的课题有： 2008-2011: Edmund Safra Foundation (joint grant) 2008-2011: Israel Science Foundation, Personal Grant 2007-2010: Wolfson Foundation Grant (joint grant) 2008-2009: Israel Science Foundation, Equipment grant 2007-2009: Marie Curie International Re-Integration Grants. 2007-2010: Ma’of fellowship: Established by the Kahanoff Foundation. The fellowship covers three consecutive years of the university salary + 30K for research budget. 等等。 最近发表论文情况： 35.Ashraf Brik* "New Strategies for Glycopeptides, Neoglycopeptides and Glycoproteins Synthesis" Comprehensive Natural Products Chemistry-II, In press 34. K. S Ajish Kumar, Ziv Harpaz, Mahmood Haj-Yahya and Ashraf Brik* "Side-Chain Assisted Ligation in Protein Synthesis" Bioorganic & Medicinal Chemistry Letters, In press 33. Natalia Nepomniaschiy, Valerie Grimminger, Aviv Cohen,Saviana DiGiovanni, Hilal Lashuel* and Ashraf Brik* "Switch Peptide via Staudinger Reaction" Organic Letters, 2008, 11, 5243-5246. PDF 32. Ashraf Brik* "Metathesis in Peptides and Peptidomimetics" Advanced Synthesis and Catalysis, 2008, 350, 1661-1675 PDF 31. Clay S. Bennett, Richard J. Payne, Simon Ficht, Stephen M. Dean, Ashraf Brik, and Chi-Huey Wong "Sugar-Assisted Glycopeptide Ligation with Complex Oligosaccharides" Journal of The American Chemical Society, 2008, 130, 11945-11952. PDF 30. Michael J. Giffin, Holly Heaslet, Ashraf Brik, Ying-Chuan Lin, Gabrielle Cauvi1, Chi-Huey Wong, Duncan E. McRee, John H. Elder, C. David Stout and Bruce E. Torbett1 "AB2, an Azide-Alkyne Click Compound, is a Potent Protease Inhibitor of Multidrug-Resistant HIV-1" Journal of Medicinal Chemistry, 2008, 51, 6263-6267. PDF 29. Marina-Yamit Lutsky, Natalia Nepomniaschiy and Ashraf Brik*, "Peptide Ligation via Side-Chain Auxiliary" Chemical Communications, 2008, 10, 1229-1231 PDF 28. Chi-Huey Wong, Ashraf Brik, Yu-Ying Yang, Simon Ficht, Richard Payne “Method of preparing glycopeptides” PCT Int. Appl. (2007), CODEN: PIXXD2 WO 2007111952 A2 20071004 AN 2007:1116927 27. Richard J. Payne, Simon Ficht, Sishi Tang, Ashraf Brik, Yu-Ying Yang, David A. Case and Chi-Huey Wong, “Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope and Applications” Journal of The American Chemical Society, 2007, 129, 13527-13536. PDF 26. Yu-Ying, Yang, Simon Ficht, Ashraf Brik* and Chi-Huey Wong* “Sugar-Assisted Ligation in Glycoprotein Synthesis” Journal of the American Chemical Society, 2007, 129, 7690-7701 (* corresponding author) PDF 25. Ashraf Brik* and Chi-Huey Wong* “Sugar-Assisted Ligation for the Synthesis of Glycopeptides” Chemistry-A European Journal,2007, 13, 5670-5675 (*corresponding author) PDF 24. Simon Ficht, Richard J. Payne, Ashraf Brik and Chi-Huey Wong “Second Generation Sugar-Assisted ligation: An effective New Method for the Synthesis of Cysteine Containing Glycopeptides” Angewandte Chemie International Edition, 2007, 46, 5975-5979 PDF 23. Ashraf Brik,* Simon Ficht, Yu-Ying Yang, and Chi-Huey Wong* “Sugar Assisted ligation for the Synthesis of N-linked Glycopeptide with Broad Sequence Tolerance at the Ligation Junction” Journal of the American Chemical Society, 2006, 128, 15026-15033. (* corresponding author), See highlight about this paper in News & Views, Nature, 2007, 445, 31-33 PDF 22. Ashraf Brik, Simon Ficht, and Chi-Huey Wong “Strategies for the Preparation of Homogenous Glycoproteins” Current Opinion in Chemical Biology, 2006, 10, 1-7 PDF 21. Ying-Chuan Lin, Ashraf Brik, Aymeric de Parseval, Karen Tam, Bruce Torbett, Chi-Huey Wong, and John H. Elder “Altered Gag-Pol Polyprotein Cleavage Specificity of FIV/HIV Mutant Proteases as Demonstrated in Cell-Based Expression System” Journal of Virology, 2006, 80, 7832-7843 PDF 20. Ashraf Brik, Yu-Ying Yang, Simon Ficht and Chi-Huey Wong, “Sugar Assisted Glycopeptide Ligation” Journal of The American Chemical Society, 2006, 128, 5626-5627 PDF 19. Ashraf Brik, Chung-Yi Wu and Chi-Huey Wong “Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery" Organic & Biomolecular Chemistry, 2006, 4, 1446-1457 PDF 18. Fu-Sen Liang, Ashraf Brik, Ying-Chuan Lin, John H. Elder, and Chi-Huey Wong. “Epoxide Opening in Water for Rapid Inhibitor Discovery in Microtiter Plate and In situ screening” Bioorganic & Medicinal Chemistry, 2006, 14, 1058-1062 PDF Sample Text [ Last edited by superman900 on 2009-4-7 at 14:49 ] |
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