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Expected Introduction Concentration (EIC) in Water Even with the increase in use expected with the supplemental indication, the maximum amount used annually in the United States is still predicted to be less than 100,000 kg of duloxetine (free base) as estimated in the original environmental assessment. From this forecast, the expected introduction concentration (EIC) of duloxetine at the point of entry into the aquatic environment is calculated as follows: 2.1¦Ìg/L 1.3 10 L/day 365 days 100,000 kg 1,000,000,000 ¦Ìg/kg EIC (ppb) aquatic 11 = ¡Á ¡Á = ¡Á where 1.3x1011 L/day is the volume of water entering publicly owned treatment works in the United States (Environmental Protection Agency, 2000 Needs Survey, Report to Congress). |
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