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NUS化学系KOH Ming Joo (许民瑜)教授课题组招博士生
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推荐个科研大牛在新加坡国立化学系新组的招人信息~ 我同级+室友，Hoveyda组大弟子，五年PhD里4篇nature,1篇science！ 现在在NUS任职，想在有机化学领域做出一些成果的同学一定不要错过这个机会！ 下一个nature你就是一作！ Assistant Professor Koh Ming Joo (许民瑜) (President's Assistant Professor) 2012–2018: Ph.D. & Post-Doc in Organic Chemistry, Boston College, MA, USA 2008–2012: B.Sc. in Chemistry & Biological Chemistry, First Class Honors, Nanyang Technological University, Singapore Ph.D. Positions Available We have positions available in August 2019 for individuals who are interested in pursuing Ph.D. studies in Singapore. Talented and self-motivated chemists with a strong background in synthetic organic chemistry, organometallic chemistry, fluorine chemistry, medicinal chemistry and/or natural product synthesis are welcome to join us. Good English proficiency and communication skills are mandatory. The deadline for online application is 15 November 2018. Please visit Dr. Koh's webpage at https://www.chemistry.nus.edu.sg/people/academic_staff/kohmj.htm and send an electronic copy of your curriculum vitae (CV) and research summary to Dr. Koh at chmkmj@nus.edu.sg. For further enquiries, please contact Dr. Koh via email. For more information on the chemistry department and online application, please visit: https://www.chemistry.nus.edu.sg ... issionCriteria.htm. Research Interests Stereoselective catalysis has revolutionized the art of chemical synthesis and tremendous progress has been made in this area over the last few decades. Despite these advances, many existing protocols suffer from poor applicability and often rely on catalyst systems that contain increasingly expensive noble metals. The high cost and limited availability of these metals makes it compelling to search for more economical and sustainable alternatives. The key objective of our program is to develop sustainable and enabling catalytic solutions that address critical and unresolved problems in chemical synthesis. Our research approach will leverage creative, direct and unprecedented disconnections of complex target molecules to fuel our efforts in devising practical stereoselective methods that utilize abundant, biocompatible and inexpensive catalysts. Insights gained from mechanistic studies will aid us in designing new catalyst systems that promote transformations to facilitate economically and environmentally viable preparation of important compounds for the chemical, pharmaceutical and polymer industries. Current topics of interest include: (a) development of catalytic transformations involving organohalides for rapid assembly of bioactive natural products and pharmaceuticals, (b) design and preparation of novel fluorinated building blocks for medicinal and polymeric material applications and (c) discovery of new reactivity patterns and transformations for engaging radicals in enantioselective catalysis. We cordially welcome collaborations in all areas of research including total synthesis, computational studies, chemical biology and materials science. Contact Information MD1-17-03C Department of Chemistry, National University of Singapore 12 Science Drive 2 Singapore 117549 Email: chmkmj@nus.edu.sg Research Publications 1. Nguyen, T. T.*; Koh, M. J.*; Mann, T. J.; Schrock, R. R.; Hoveyda, A. H. “Synthesis of E- or Z-Trisubstituted Alkenes by Catalytic Cross-Metathesis” Nature 2017, 552, 347. (*these authors contributed equally). 2. Koh, M. J.; Nguyen, T. T.; Lam, J. K.; Torker, S.; Hyvl, J.; Schrock, R. R.; Hoveyda, A. H. “Molybdenum Chloride Catalysts for Z-Selective Olefin Metathesis Reactions” Nature 2017, 542, 80. 3. Shen, X.; Nguyen, T. T.; Koh, M. J.; Xu, D.; Speed, A.W. H.; Schrock, R. R.; Hoveyda, A. H. “Kinetically E-Selective Macrocyclic Ring-Closing Metathesis” Nature 2017, 541, 380. 4. Nguyen, T. T.; Koh, M. J.; Shen, X.; Romiti, F.; Schrock, R. R.; Hoveyda, A. H. “Kinetically Controlled E-Selective Catalytic Olefin Metathesis” Science 2016, 352, 569. (highlighted by C&EN News). 5. Koh, M. J.; Nguyen, T. T.; Zhang, H.; Schrock, R. R.; Hoveyda, A. H. “Direct Synthesis of Z-Alkenyl Halides by Catalytic Cross-Metathesis” Nature 2016, 531, 459. (highlighted by Nature, C&EN News, Organic Chemistry Portal, SYNFACTS, Synfacts 2016, 12, 603). 6. Torker, S.; Koh, M. J.; Khan, R. K. M.; Hoveyda, A. H. “Regarding a Persisting Puzzle in Olefin Metathesis with Ru Complexes: Why are Transformations of Alkenes with a Small Substituent Z-selective?” Organometallics 2016, 35, 543. 7. Koh, M. J.; Khan, R. K. M.; Torker, S.; Yu, M.; Mikus, M. S.; Hoveyda, A. H. “High-Value Alcohols and Higher-Oxidation-State Compounds by Catalytic Z-Selective Cross-Metathesis” Nature 2015, 517, 181. (highlighted by SYNFACTS, Synfacts 2015, 11, 387). 8. Koh, M. J.; Khan, R. K. M.; Torker, S.; Hoveyda, A. H. “Broadly Applicable Z- and Diastereoselective Ring-Opening/Cross-Metathesis Catalyzed by a Dithiolate Ru Complex” Angew. Chem. Int. Ed. 2014, 53, 1968. 9. Teo, W.; Rao, W.; Koh, M. J.; Chan, P. W. H. “Gold-Catalyzed Domino Aminocyclization/1,3-Sulfonyl Migration of N-Substituted-N-Sulfonyl-aminobut-3-yn-2-ols to 1-Substituted-3-Sulfonyl-1H-pyrroles” J. Org. Chem. 2013, 78, 7508. 10. Rao, W.; Koh, M. J.*; Li, D.*; Hirao, H.; Chan, P. W. H. “Gold-Catalyzed Cycloisomerization of 1,6-Diyne Carbonates and Esters to 2,4a-Dihydro-1H-fluorenes” J. Am. Chem. Soc. 2013, 135, 7926. (*these authors contributed equally). 11. Rao, W.; S.; Koh, M. J.; Chan, P. W. H. “Gold-Catalyzed Cycloisomerization of 1,7-Enyne Esters to Structurally Diverse cis-1,2,3,6-Tetrahydropyridin-4-yl Ketones” J. Org. Chem. 2013, 78, 3183. 12. Sze, E. M. L.; Koh, M. J.*; Tjia, Y. M.*; Rao, W.; Chan, P. W. H. “Synthesis of (Z)-1,2-Dihydro-1-tosylbenzoazepin-3-ones by Two-step, One-Pot Gold-Catalyzed Tandem Heterocyclization/Petasis-Ferrier Rearrangement of 2-(N-(Prop-2-ynyl)-N-tosylamino)benzaldehydes” Tetrahedron 2013, 69, 7471. (*these authors contributed equally). (highlighted by SYNFACTS, Synfacts 2013, 9, 945). 13. Rao, W.; Koh, M. J.; Kothandaraman, P.; Chan, P. W. H. “Gold-Catalyzed Cycloisomerization of 1,7-Diyne Benzoates to Indeno[1,2-c]azepines and Azabicyclo[4.2.0]octa-1(8),5-dines” J. Am. Chem. Soc. 2012, 134, 10811. (highlighted by SYNFACTS, Synfacts 2012, 9, 952). 14. Sze, E. M. L.; Rao, W.; Koh, M. J.; Chan, P. W. H. “Gold-Catalyzed Tandem Intramolecular Heterocyclization/Petasis–Ferrier Rearrangement of 2-(Prop-2-ynyloxy)benzaldehydes as an Expedient Route to Benzooxepin-3(2H)-ones” Chem. Eur. J. 2011, 17, 1437. Patents 1. Hoveyda, A. H.; Nguyen, T. T.; Koh, M. J.; Xu, C.; Torker, S. “Method of Preparing Trisubstituted Ethylene Compounds,” U.S. Patent Application No. 62/562,224, filed September 22, 2017. 2. Hoveyda, A. H.; Koh, M. J.; Nguyen, T. T.; Schrock, R. R.; Hyvl, J. “Halogen-Containing Metathesis Catalysts and Methods Thereof,” U.S. Patent Application No. 62/363,066, filed July 15, 2016. 3. Hoveyda, A. H.; Zhang, H.; Koh, M. J.; Schrock, R. R. “Metathesis Catalysts and Methods Thereof,” PCT Int. Appl. WO2016073750 A1, May 12, 2016. 4. Hoveyda, A. H.; Khan, R. K. M.; Torker, S.; Koh, M. J. “Catalysts for Efficient Z-Selective Metathesis,” PCT Int. Appl. WO2014201300 A1, December 18, 2014. |
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