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444号便利店

金虫 (小有名气)

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[求助] 盐酸右美托咪定晶型的问题已有1人参与

盐酸右美托咪定有没有原研晶型文献报告，有的话求文献，谢谢各位大佬了:cat39

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1楼 2018-08-09 16:18:54

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

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444号便利店: 金币+50, ★★★很有帮助, 基本上是所需要的 2018-08-10 15:31:05

晶形未见原研的描述：不过在EMA的审评报告中提到过，本品存在两种晶形形式，无水物和一水合物，其中无水物被用作制成制剂。
It appears as an almost white, or white, crystalline powder that is freely soluble in water, chloroform,ethanol and methanol; slightly soluble in acetonitrile and practically soluble in ethe. Dexmedetomidinehas one chiral centre and is therefore optically active. During the synthesis only one (S)-enantiomer is manufactured and used in the manufacture of the finished product. There are two recognisedpolymorphic forms of dexmedetomidine: anhydrous (form A) and monohydrate (form B). Form A is consistently obtained during synthesis and is used in the manufacture of the finished product.

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