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3Â¥2018-07-19 16:27:38
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4Â¥2018-07-19 20:50:16
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5Â¥2018-07-19 22:28:26
20093651
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Dear Editors: We would like to submit the enclosed manuscript entitled ¡°XXX¡±, which we wish to be considered for publication in ¡°ACS Nano¡±. The manuscript is original and not under consideration for publication in another journal. Widespread bacterial resistance induced by the abuse of antibiotics eagerly needs the exploitation of novel antimicrobial agents and strategies. Gold nanoclusters (Au NCs) have recently emerged as an innovative nanomedicine, but study on their antibacterial properties especially towards multidrug resistant (MDR) bacteria is scarce. Herein, we demonstrate that a novel class of Au NCs, mercaptopyrimidine capped Au NCs, can act as potent nanoantibiotics targeting these intractable superbugs (notorious ¡°ESKAPE¡± as models) in vitro and in vivo, without induction of bacterial antibiotic resistance and noticeable cytotoxicity to mammalian cells. The Au NCs kill these superbugs through a combined mechanism including cell membrane destruction, DNA damage, and reactive oxygen species (ROS) generation, and exhibit excellent treatment effects in both macrophages and animal infection models induced by methicillin-resistant Staphylococcus aureus as representatives. Moreover, the induction of intracellular ROS production in bacterial cells mainly attributed to the Au NCs¡¯ intrinsic oxidase- and peroxidase-like catalytic activities has been demonstrated for the first time. I hope this paper is suitable for ¡°ACS Nano¡±. We deeply appreciate your consideration of our manuscript. If you need further information, please don¡¯t hesitate to contact me soon. Thank you and best regards. XXX |

6Â¥2018-07-19 22:29:10
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9Â¥2019-07-15 16:55:25
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