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李红良教授武汉大学基础医学院
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研究方向： 1.心血管代谢性疾病的发生机制与防治；研究免疫机制、信号传导通路在心血管代谢性疾病发生发展中的作用及其机制。 2.生物医学工程：基因敲除及转基因动物模型的构建。 代表性论著： 1.Zhao GN, Zhang P, Gong J, Zhang XJ, Wang PX, Jiang Z, Shen LJ, Ji YX, Tong JJ, Wang YT, Wei QF, Wang Y, Zhu XY, Zhang X, Fang J, She ZG, Wang ZH, Huang Z, Li H*, TMBIM1 protects against nonalcoholic steatohepatitis in mice and monkeys by targeting TLR4 for lysosomal degradation, Nat Med., 2017 ;23(6):742-752. 2.Wang PX, Ji YX, Zhang XJ, Zhao LP, Yan ZZ, Zhang P, Shen LJ, Yang X, Fang J, Tian S, Zhu XY, Gong J, Zhang X, Wei QF, Wang Y, Li J, Wan L, Xie QG, She ZG, Wang ZH, Huang Z, Li H*, Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates, Nat Med.2017;23(4):439-449. 3.Wang ZH, Zhang XJ, Zhang P, Wang XH, Chen I, Gao C, Deng KQ, Gong J, Yokota T, Wang H, Cass A, Ren SX, Vondriska T, Li GP, Yang HT, Xiao XS, Li H*, Wang Y*, A long non- coding RNA defines an epigenetic check point for cardiac hypertrophy. Nat Med. 2016 ,22(10):1131-1139. 4.Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, Zhao G, Zhu X, Zhang Y, Yang S and Li H*. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016; 7：10592. 5.Ji Y, Zhang P, Zhang X, Zhao Y, Deng K, Jiang X, Wang P, Huang Z and Li H*. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Nat Commun. 2016; 7：11267. 6.Deng K, Wang A, Ji Y, Zhang X, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu X, Zhao Y, Gao L, Yang Q, Zhu X, Wei X, Pu J and Li H*. Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016; 7：11432. 7.Zhang S, Zhu L, Chen H, Zhang R, Zhang P, Jiang D, Gao L, Tian S, Wang L, Zhang Y, Wang P, Zhang X, Zhang X, Liu D and Li H*. Interferon regulatory factor 9 is critical for neointima formation following vascular injury. Nat Commun. 2014; 5：5160. 8.Jiang D, Wei X, Zhang X, Liu Y, Zhang Y, Chen K, Gao L, Zhou H, Zhu X, Liu PP, Bond Lau W, Ma X, Zou Y, Zhang X, Fan G and Li H*. IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurinsignalling. Nat Commun. 2014; 5：3303. 9.Lu Y, Li Z, Jiang D, Wang L, Zhang Y, Chen K, Zhang X, Liu Y, Fan G, Chen Y, Yang Q, Zhou Y, Zhang X, Liu D and Li H*. TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death. Nat Commun. 2013; 4：2852. 10.Xiang M, Wang P, Wang A, Zhang X, Zhang Y, Zhang P, Mei F, Chen M and Li H*. Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. J Hepatol. 2016; 64：1365-1377. 11.Hu J, Zhu X, Zhang X, Wang P, Zhang R, Zhang P, Zhao G, Gao L, Zhang X, Tian S and Li H*. Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury. J Hepatol. 2016; 64：146-159. 12.Gao L, Wang P, Zhang Y, Yu C, Ji Y, Wang X, Zhang P, Jiang X, Jin H, Huang Z, Zhang Z and Li H*. Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. J Hepatol. 2016;65:125-36. 13.Wang P, Zhang R, Huang L, Zhu L, Jiang D, Chen H, Zhang Y, Tian S, Zhang X, Zhang X, Liu D and Li H*. Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury. J Hepatol. 2015; 62：111-120. 14.Zhu L, Wang A, Luo P, Wang X, Jiang D, Deng W, Zhang X, Wang T, Liu Y, Gao L, Zhang S, Zhang X, Zhang J and Li H*. Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice. J Hepatol. 2014; 60：1046-1054. 15.Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z, Li H*. The E3 ligase TRIM8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017;65(5):1492-1511. 16.Wang X, Zhang R, She Z, Zhang X, Jiang D, Wang T, Gao L, Deng W, Zhang S, Zhu L, Guo S, Chen K, Zhang X, Liu D and Li H*. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology. 2014; 59：870-885. 17.Zhang Y, Zhang XJ, Wang PX, Zhang P, Li H*.Reprogramming Innate Immune Signaling in Cardiometabolic Disease. Hypertension. 2017;69(5):747-760. 18.Zhu X, Fang J, Gong J, Guo J, Zhao G, Ji Y, Liu H, Wei X and Li H*. Cardiac-Specific EPI64C Blunts Pressure Overload–Induced Cardiac HypertrophyNovelty and Significance. Hypertension. 2016; 67：866-877. 19.Gong J, Li Z, Guo S, Zhang X, Zhang P, Zhao G, Gao L, Zhang Y, Zheng A, Zhang X, Xiang M and Li H*. Neuron-Specific Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Hypertension. 2015; 66：604-616. 20.Zhang X, Zhang P and Li H*. Interferon Regulatory Factor Signalings in Cardiometabolic Diseases. Hypertension. 2015; 66：222-247. |
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