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[求助]
求助查询一种原料药的物理性质：pKa，lgP，分配系数，摩尔吸收系数等尽可能详细 已有1人参与
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Diflucortolone valerate（戊酸二氟可龙） CAS：59198-70-8 是不是默克索引可以查？求各位大能指导！！ 发自小木虫Android客户端 |
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25金币微谱求助，谢谢
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【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
lxm5185: 金币+5, ★有帮助, 想要的一些物理参数还是没有，谢谢 2018-04-08 12:59:47
感谢参与，应助指数 +1
lxm5185: 金币+5, ★有帮助, 想要的一些物理参数还是没有，谢谢 2018-04-08 12:59:47
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Monograph Number: 0003143 Title: Diflucortolone CAS Registry Number: 2607-06-9 CAS Name: (6a, 11b, 16a)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione Additional Names: 6a,9a-difluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione; 6a,9a-difluoro-16a-methyl-1-dehydrocorticosterone Molecular Formula: C22H28F2O4 Molecular Weight: 394.45 Percent Composition: C 66.99%, H 7.15%, F 9.63%, O 16.22% Literature References: The 9a-fluoro deriv of fluocortolone, q.v. Prepn: BE 639708; K. Kieslich et al., US 3426128 (1964, 1969, both to Schering AG); eidem, Arzneim.-Forsch. 26, 1462 (1976). Toxicity: P. Gunzel et al., ibid. 1476. Series of articles on pharmacology, toxicity, metabolism and clinical studies: ibid. 26, 1463-1513 (1976). Properties: Crystals from ethyl acetate-ether, mp 240-244°. uv max: 237 nm (e 16600) (Kieslich, 1969). Also reported as mp 248-249°. [a]D22 +111° (methanol) (Kieslich, 1976). Melting point: mp 240-244°; mp 248-249° Optical Rotation: [a]D22 +111° (methanol) (Kieslich, 1976) Absorption maximum: uv max: 237 nm (e 16600) (Kieslich, 1969) Derivative Type: 21-Valerate CAS Registry Number: 59198-70-8 Trademarks: Neribas (Schering AG); Neriforte (Schering AG); Nerisona (Schering AG); Nerisone (Schering AG); Temetex (Sauter); Texmeten (Roche) Molecular Formula: C27H36F2O5 Molecular Weight: 478.57 Percent Composition: C 67.76%, H 7.58%, F 7.94%, O 16.72% Properties: Crystals, mp 195-195.5°. [a]D22 +100.8° (dioxane). Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel). Melting point: mp 195-195.5° Optical Rotation: [a]D22 +100.8° (dioxane) Toxicity data: Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel). Therap-Cat: Anti-inflammatory. Keywords: Glucocorticoid. |
2楼2018-04-08 11:59:19
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