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宜兰

铁虫 (小有名气)

应助: 0 (幼儿园)
金币: 16.2
散金: 52
帖子: 110
在线: 50小时
虫号: 1076453
注册: 2010-08-17
专业: 药物毒理

[求助] 投稿遇到修回，这个问题怎么回答最好已有1人参与

新手第一次投稿，有些问题不懂还请各位前辈帮忙。
问题一：我的实验是评价一个药物的抗抑郁药效，实验过程大致如下：开始第1周进行糖水偏爱实验（Sucrose preference test ，SPT）观察大鼠的糖水偏爱的基础值，然后进行6周的慢性应激（CUMS），再次进行SPT评价抑郁状态，以及其他的行为学实验（FST,OFT）。数据统计我采用了one way ANOVA，但是审稿的意见如下：
The work presented by Wang et al. is focused on the study of the antidepressant efficacy of A. The work is quite well depicted by I have a big concern about the statistics. In the section of methods Authors stated that they used one way ANOVA. According to the groups, however, The correct test should be at least the two-way ANOVA considering 2 variables: CUMS and treatment.
In regard to fig1 and thus SPT results, in this case at least two-way ANOVA repeated measures should be used. Indeed, time and treatment should be considered. I suggest to change the way the figure has been shown because in the way it is a three way ANOVA RM should be use used. However, this analysis makes results very difficult to be described and understood.
审稿人的意见是要采用two-way ANOVA，但是我在实验时已经没有在应激了（CUMS），并且我实验也只是检测一次，感觉进行不了two-way ANOVA，如何回复审稿人？

这是我大概实验流程（图表是来自文献）

问题二：Furthermore, in the result section, statistical tests used should be repeated before p values as well as in the figure legends.
不大明白这句话的意思，是不是可以理解为，在文章和图注中的P值出现前都要再提一下统计学方法，例如：我的文章里面（fluoxetine (10 mg/kg) effectively reversed the decline of sucrose preference in a dose-dependent manner, compared with the stressed rats [F(5, 54) = 7.534, P < 0.05, P < 0.01, P < 0.01 respectively]）是不是前面都要加一个类似：One way ANOVA revealed that………..。
谢谢大家，第一次投稿不是很熟悉。

fig1（SPT）.png