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冷月5565木虫 (职业作家)
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[交流]
以下四种物质有区别吗？
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viral particle和virosome、virus particle中文含义都是“病毒颗粒“。他们是否指代同一种物质？viral like particle（VLP）和他们有没有不同点？ [ Last edited by 冷月5565 on 2009-3-14 at 10:31 ] |
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lwf991229(金币+3,VIP+0):辛苦~ 3-16 10:27
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virosome, A virosome is a unilamellar phospholipid bilayer vesicle with a mean diameter of 150 nm. Essentially, virosomes represent reconstituted empty influenza virus envelopes, devoid of the nucleocapsid including the genetic material of the source virus. Virosomes are not able to replicate but are pure fusion-active vesicles. In contrast to liposomes, virosomes contain functional viral envelope glycoproteins: influenza virus hemagglutinin (HA) and neuraminidase (NA) intercalated in the phospholipid bilayer membrane. The unique properties of virosomes partially relate to the presence of biologically active influenza HA in their membrane. This viral protein not only confers structural stability and homogeneity to virosome-based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. It has been shown that a physical association between the virosome and the antigen of interest is necessary for the full adjuvant effect of virosomes. Such physical association can be achieved by a variety of methods, depending on the properties of the antigen. Antigens can be incorporated into virosomes, adsorbed to the virosome surface, or integrated into the lipid membrane, either via hydrophobic domains or lipid moieties cross-linked to the antigen. viral particle, The new viruses reproduced inside of a cell. virus particle, 就是指包装好，处于可感染状态的病毒颗粒。 VLP，指得是病毒样粒子，不见得就是病毒，或者说包括了很多状态的病毒，如没有成功包装的病毒、构造的假病毒等等都算是病毒样粒子。前两个解释来自于维基百科。我不能肯定其的绝对准确性。 |
2楼2009-03-14 23:39:51
冷月5565
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3楼2009-03-16 09:48:35