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【答案】应助回帖
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杨德良: 金币+70, 翻译EPI+1, ★★★★★最佳答案 2018-03-06 01:19:54
【摘要】目的：通过对 多西紫杉醇 的 血药浓度检测，探究其 药时曲线下面积（AUC）与 毒性 和 近期疗效 的关系，初步确立多西紫杉醇的治疗窗AUC范围。方法：167例 实体瘤患者，接受 含多西紫杉醇药物 的 3周治疗方案，采集 滴注结束 前10min 至结束 和 滴注结束后 30-60min的血样，测定其 血药浓度 并计算AUC值。统计分析多西紫杉醇AUC值 与 中性粒细胞减少发生率 的相关性，以及AUC值近期疗效的相关性。结果：167例患者，多西紫杉醇AUC值分布为0.5-4.1mg.h/L，AUC平均值为1.6 mg.h/L，变异系数为41.35%。发生3级及以上 中性粒细胞减少患者（17例）的AUC值 大于2.7 mg.h/L，与3级以下中性粒细胞减少 患者（150例）相比P值等于0.00。多西紫杉醇AUC值＞1.5 mg.h/L的临床获益率（80.8%）与＜1.5 mg.h/L的临床获益率（0%）相比，P=0.00。结论：多西紫杉醇的AUC值1.5-2.7 mg.h/L，可以作为 多西紫杉醇 临床参考的 药代动力学治疗窗。
Abstract: Purpose: through detecting the plasma concentration of docetaxel, we explored the correlation between short-term effect and AUC(area under the curve) & toxicity of docetaxel, and established inital therapeutic window AUC range of docetaxel. Method: 167 patients with solid tumor were selected as research objects and subjected to 3 weeks of docetaxel drug treatment. After that the blood sample from 10 min before ending docetaxel infusion to infusion ending point as well as the blood sample from 30 to 60 min after ending docetaxel infusion were collected for measuring plasma concentration of docetaxel and calculating AUC value. Statistical analysis was conducted to investigate the correlation between docetaxel AUC value and neutropenia incidence rate as well as the corealtion between AUC value and short-term effect. Results: for the 167 patients, docetaxel AUC value ranged from 0.5 to 4.1mg.h/L, averaging at 1.6 mg.h/L, with variable coefficient of 41.35%. There were 17 patients showing grade-3 or above neutropenia, with AUC value over 2.7 mg.h/L; there were 150 patients showing grade-3 or below neutropenia. In comparison of AUC value between the two groups, p=0.00. In comparison of clinical benefit rate (80.8%) upon docetaxel AUC ＞1.5 mg.h/L and that upon docetaxel AUC ＜1.5 mg.h/L, it could be found that p value is equal to 0. Conclusion: The docetaxel AUC value of 1.5-2.7 mg.h/L can be adopted as referential pharmacokinetic therapeutic window for docetaxel clinical treatment. |
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