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红苹果3763

金虫 (小有名气)

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虫号: 1823453
注册: 2012-05-17
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[交流] 美国梅奥诊所（Mayo Clinic in Florida）招聘神经疾病研究方向公派出国学生或访问学者

Mayo Clinic是美国最好的医院， Mayo 医学中心排名第一。

研究所在美国Jacksonville， Florida。离海边非常近，环境优美，资源设施先进。

研究方向：
1. Disease mechanisms in SMA. Spinal muscular atrophy (SMA) is the most common genetic cause of death for infants. Dr. Rossoll's team is using advanced cellular and animal models to study the molecular functions of the disease protein SMN, how reduced levels of this protein cause a deficiency of RNA-protein assembly, and the degeneration of motor neurons in SMA.
2. Mechanisms of protein aggregation in neurological disease. Research in Dr. Rossoll's lab is focused on aggregation-prone proteins such as TDP-43 and tau, which are critically involved in the pathogenesis of ALS, FTD and Alzheimer's disease. Studies in the lab seek to gain a detailed understanding of the aggregate-associated proteome, mechanisms that promote the aggregation, and how to prevent the pathology from occurring and spreading across the central nervous system.
3. Modifiers and novel therapeutic targets of disease progression. Dr. Rossoll's team recently discovered a potent modifier of pathological TDP-43 aggregation, which is a hallmark of FTD, ALS and other neurodegenerative diseases. His team is utilizing cutting-edge techniques in the areas of biochemistry, molecular and cell biology, and fluorescence microscopy to identify ways to prevent the formation of pathological protein aggregates in various cell models including patient-derived cells and in vivo models.

实验室PI: WILFRIED O. ROSSOLL. 简介：http://www.mayo.edu/research/fac ... o-ph-d/bio-20358600

要求留学生或访问学者有CSC资助，交流时间为一年, MD交流时间可以延长。欢迎申请国家公派留学项目的同学去学习交流。

本招聘长期有效，感兴趣请发送简历CV至：Rossoll.Wilfried@mayo.edu

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