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synhily木虫 (正式写手)
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| THI3 is ORF YDL080c that encodes a protein with striking similarity to pyruvate decarboxylase (Pdc). The homology is extensive throughout the protein and all amino acid residues of Pdc that have been shown to be involved in ThDP binding, both of the thiazole and phosphate moieties, are precisely conserved in Thi3p. Thus Thi3p may be the protein that senses changes in the intracellular level of the negative e¡ector ThDP in order to exert transcriptional control. However, Thi3p has no similarity to any known transcriptional regulator and must therefore act via interaction with other protein(s), possibly Thi2p. Thi3p may also have enzymatic function. Recent studies on catabolism of leucine to isoamyl alcohol have implicated YDL080c as the structural gene (KID1) of K-ketoisocaproic acid decarboxylase. |
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synhily(金币+3,VIP+0):谢谢你啦！ 3-12 10:37
synhily(金币+3,VIP+0):谢谢你啦！ 3-12 10:37
| THI3(T辅助诱导细胞3)是羊痘YDL080c编码的蛋白质,与丙酮酸脱羧酶（ PDC ）有惊人的相似之处。整个蛋白具有广泛的同源性，并且丙酮酸脱羧酶的氨基酸残基，已被证明参与了ThDP结合，双方的噻唑和磷酸基，都精确的保存在Thi3p中 。因此Thi3p可能是蛋白质，对细胞内水平的的负极e¡变化非常敏感；载体ThDP 用于发挥转录调控作用。然而， Thi3p与任何已知的转录调节剂没有相似之处，而且必须通过与其他蛋白，可能是Thi2p的相互作用才能产生反应 。 Thi3p也可能具有酶的功能。最近关于亮氨酸分解代谢为异戊醇的研究表明， YDL080c是作为K - ketoisocaproic谷氨酸脱羧酶的结构基因（ KID1 ）。 |
2楼2009-03-12 01:18:25
synhily
木虫 (正式写手)
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| 请大家来翻译，特别是这句话：Thus Thi3p may be the protein that senses changes in the intracellular level of the negative effector ThDP in order to exert transcriptional control. However, Thi3p has no similarity to any known transcriptional regulator and must therefore act via interaction with other protein(s), possibly Thi2p. |
3楼2009-03-12 12:20:58