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°ÄÃÅ´óѧ³ÂнÌÊÚ (Professor Xin CHEN) ¿ÎÌâ×é2018ÄêÕÐÊÕ˶ʿÑо¿Éú£¬²©Ê¿Ñо¿Éú, ²©Ê¿ºóÑо¿Ô±
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Selective recent publications (* corresponding or co-corresponding author):
1. Yingjie Nie, Jiang He, Hidekazu Shirota, Anna L. Trivett, De Yang, Dennis M. Klinman, Joost J. Oppenheim, Xin Chen*. Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer. Science Signaling 2018. Jan 2. 11(511): pii: eaan0790. pii: eaan0790. doi: 10.1126/scisignal.aan0790
2. Shuoyang Liu and Xin Chen*. Dietary Therapy May Be Sufficient for Type 1 Diabetes Treatment. Cellular and Molecular Immunology. 2018 Feb;15(2):85-87. doi: 10.1038/cmi.2017.56.
3. Ping Li, Ying Zheng and Xin Chen*. Drugs for Autoimmune Inflammatory Diseases: from Small Molecule Compounds to anti-TNF Biologics. Frontiers in Pharmacology. 2017 Jul 12;8:460. doi: 10.3389/fphar.2017.00460.
4. Xin Chen* and J.J. Oppenheim, Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer. Science Signaling 2017. 10(462). pii: eaal2328. doi: 10.1126/scisignal.aal2328
5. Yingjie Nie, De Yang, Anna Trivett, Haiyun Xin, Zhen Han, Xin Chen, Joost J. Oppenheim. Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Big Solid Tumors. Scientific Reports 2017 Oct 27;7(1):14186. doi: 10.1038/s41598-017-14655-8.
6. Xin Chen*, and Joost J Oppenheim. Paradoxical effects of anti-TNF treatment of autoimmunity. Nature Reviews Rheumatology. 2016. 2016 Nov;12(11):625-626. doi: 10.1038/nrrheum.2016.145.
7. B Zaragoza, Xin Chen, JJ Oppenheim, D Chader, M Miyara and BL Salomon. Suppressive activity of human Treg cells is maintained in the presence of TNF. Nature Medicine. 2016 Jan 22:16-17. doi: 10.1038/nm.4019.
8. Fan Yan, Ruijuan Du, Feng Wei, Hua Zhao, Jingpu Yu, Changli Wang, Zhongli Zhan, TingTing Ding, Xiubao Ren, Xin Chen*, Hui Li. Expression of TNFR2 by regulatory T cells in the peripheral blood is correlated to the clinicopathology of lung cancer patients. Cancer Immunology, Immunotherapy. 2015 Nov;64(11):1475-85.
9. Ryoko Hamano, Xueqiang Wu, Yitao Wang, Joost J Oppenheim and Xin Chen*. Characterization of MT-2 cells as a human regulatory T cell-like cell line. Cellular & Molecular Immunology. 2015 Nov;12(6):780-2.
10. Xin Chen*, Jami Willette-Brown, Xueqiang Wu, Ya Hu, O.M. Zack Howard, Yinling Hu and Joost J Oppenheim. IKK¦Á is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells. FASEB J. 2015, Feb;29(2):443-54.
PIѧÊõ±³¾°£¬Çë²Î¼û£º http://www.umac.mo/sklqrcm/academic_staff/xchen_ch.html
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