| 查看: 232 | 回复: 2 | |||
| 当前主题已经存档。 | |||
meiocht铁杆木虫 (正式写手)
|
[交流]
Imaging Tumors With Degradable Nanoparticles
|
||
|
Imaging Tumors With Degradable Nanoparticles Fluorescent, porous silicon particles can also carry drugs in vivo Rachel Petkewich The first fluorescent nanoparticles that can circulate in the blood and degrade into nontoxic by-products could also help image tumors and carry cancer-fighting drugs. Michael J. Sailor, a chemist at the University of California, San Diego, and colleagues developed the porous silicon nanoparticles (Nature Mater., DOI: 10.1038/nmat2398). Although other fluorescent nanoparticles such as quantum dots are available for imaging studies, he says, the brightest dots contain cadmium selenide, which is too toxic for use in humans, whereas silicon is actually a trace nutrient in the body. In addition, porous silicon can carry drugs, unlike most nanoparticles, which are solid. The idea is to use the inherent luminescence of the particles to track them as they chaperone the drug directly to a tumor rather than to other parts of the body and then let them degrade harmlessly, Sailor adds. Sailor and his colleagues used electrochemical machining techniques to create porous silicon. They applied electrical currents to silicon wafers in an ethanolic hydrogen fluoride solution and used ultrasonic waves to break the porous wafers into 126-nm-diameter particles with 5- to 10–nm-diameter pores. Chemically degrading the surfaces of the silicon particles yielded a silicon dioxide layer that is luminescent under ultraviolet light. In mice, such particles hydrolyze to silicic acid by-products that are eliminated via urine in about 24 hours. The researchers loaded these degradable particles with the anticancer drug doxorubicin. They injected the particles into a mouse with a tumor and demonstrated with imaging that the particles aggregate in the tumor. To ensure that the particles could circulate in the body long enough to be useful, Sailor's team coated them with the polysaccharide dextran. Jarno Salonen, a physicist who studies drug delivery applications of porous silicon at the University of Turku, in Finland, praised this "pioneering" development. By modifying the pore size or the surface chemistry, one could tweak, for example, the particles' biodegradation rate as necessary, he says. He adds that porous silicon is quite versatile and can also be biofunctionalized if needed. FROM: PUBS.ACS.ORG Ji-Ho Park/UC San Diego GOING, GOING, GONE A black-and-white photograph shows a tumor in a mouse's hindquarter. The three colored images show how dextran-coated silicon nanoparticles, which were injected into the mouse's tail vein and fluoresce red, gravitate to the tumor and degrade over time. Time after injection is noted in hours. |
回复此楼» 猜你喜欢
温州大学化材学院王娟课题组招生
已经有7人回复
-
学院官方群-院士团队招生-学生自由度高-培养模式成熟已有10余名学生赴985海外深造
已经有0人回复
-
金属材料论文润色/翻译怎么收费?
已经有289人回复
-
武汉纺织大学化工学院官方群-院士团队招生-学生自由度高-10余名学生赴985海外深造
已经有0人回复
-
南昌航空大学蒋华麟教授课题组招收化学、环境、碳达峰碳中和及相关专业硕士信息
已经有0人回复
-
湖北师范大学复试调剂
已经有0人回复
-
武汉纺织大学_化工学院官方调剂群-院士团队招生-学生自由度高-每届发展好
已经有0人回复
-
河北大学材料与化工专业研究生（专硕）招收调剂生
已经有0人回复
-
河北大学无机化学专业招收调剂生
已经有0人回复
-
济南大学国家优青课题组 2026 调剂招生来啦
已经有0人回复
-
武汉纺织大学_化学院官方调剂群-院士团队招生-学生自由度高发展好-欢迎各位同学
已经有0人回复
2楼2009-03-01 09:46:19
meiocht
铁杆木虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 9290.2
- 散金: 10
- 帖子: 525
- 在线: 75小时
- 虫号: 94367
- 注册: 2005-09-27
- 性别: GG
- 专业: 有机合成
3楼2009-03-01 11:08:34
