24小时热门版块排行榜

>论坛更新日志 (3788)
>导师招生 (462)
>文献求助 (380)
>虫友互识 (373)
>休闲灌水 (189)
>考博 (183)
>硕博家园 (134)
>招聘信息布告栏 (117)
>基金申请 (90)
>论文投稿 (87)
>博后之家 (77)
>教师之家 (48)
>SciFinder/Reaxys (44)
>仿真模拟 (43)
>找工作 (43)
>考研 (40)

返回列表

当前主题已经存档。

bioinfuture

铁虫 (小有名气)

应助: 0 (幼儿园)
金币: 2.8
散金: 43
帖子: 195
在线: 9.2小时
虫号: 674534
注册: 2008-12-14
性别: GG
专业: 兽医传染病学

[交流] 哪位大虾帮我查篇文章，必有重谢

Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines

This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Janet M. Daly, , a, Philip J. Yatesa, 1, J. Richard Newtona, Andrew Parka, b, William Henleya, James L. N. Wooda, Nick Davis-Poyntera and Jennifer A. Mumforda

a Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK

b Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK

Received 5 February 2004; accepted 27 February 2004. Available online 27 April 2004.

Abstract
Two lineages of antigenically distinct equine influenza A H3N8 subtype viruses, American and European, co-circulate. Experiments were conducted in ponies to investigate the protection induced by vaccines containing virus from one lineage against challenge infection with homologous or heterologous virus. Regression analysis showed that vaccinated ponies with average pre-challenge single radial haemolysis (SRH) antibody levels (i.e. 45–190 mm2) had a higher probability of becoming infected if they were vaccinated with virus heterologous to the challenge strain than if they were vaccinated with homologous virus. Field studies in Thoroughbred racehorses also showed that SRH antibody levels of ≥150 mm2 induced by vaccines containing a European lineage strain are protective against infection with a virus from the same lineage, but that the same or higher antibody levels may not be protective against an American lineage virus. In conclusion, vaccines should contain virus strains representative of both H3N8 subtype lineages to maximise protection against infection.

回复此楼