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lixwei2012

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Why does Fig 1 use two reconbinases in two generaiton to knockout mouse whereas the strategy of Fig 2 only use 1 cre to Knockout?
Obviously, the technique of Fig 2 is easier and quicker compared with  that of Fig 1. But is there any drawback in Fig 2, or in fact, Fig 1 is easier and quicker than Fig 1 in the time of obtaining completely  conditional KO mouse. Does the approach to making conditional KO mouse provided by Fig 1 have any edges compared with Fig 2?
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https://www.researchgate.net/pos ... e_1_cre_to_Knockout
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