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2.2. Data extraction2. Methods 2.1. Literature search and study identi?cation We conducted a comprehensive literature search to identify studies describing in vivo and in vitro e?ects of exposure to melamine. The search included all articles published for all years up to November 2016. Electronic searches were performed in Web of Science and PubMed using the following search criteria: “melamine OR (5-triazine and 6-triamine) OR s-triazine-6-triamine OR 6-triamino-s-triazine OR (triazine* and triamine) OR s-triazinetriamine OR s-triazine-triamine OR triamino-triazine OR triaminotriazine OR triaminotriazines OR triazine-triamine OR triazinetriamine OR cyanuramide OR cyanurictriamide OR cyanurotriamide OR cyanurotriamine OR cyanuro-triamineORisomelamineORisomelaminesOR108-78-1”(theCASregistry number for melamine). For inclusion, the studies had to be primary literature, in the English language, and assess e?ects of melamine exposure in vitro and in vivo (excluding renal toxicity). All titles and abstracts were screened for inclusion independently by two reviewers using the software DistillerSR? (Evidence Partners, Ottawa, Ontario, Canada (Evidence Partners, 2015)). DistillerSR is software that allows A.L. Bolden et al. Toxicology Letters 280 (2017) 181–189 182 for the identi?cation of relevant studies via systematic and consistent evaluation of studies, and automates the process of con?ict resolution. Con?icts or discrepancies were resolved by discussion between the two reviewers. Data extracted included author information, year of publication, endpoint(s) evaluated, information about the model used (e.g., cell line and species), concentrations/doses tested, exposure duration, age at exposure, and route of exposure. The data were inputted by one reviewer and then quality checked by a second reviewer. Discrepancies were resolved by discussion. 发自小木虫Android客户端 |
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