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lixwei2012

木虫 (初入文坛)

Postgraduate

应助: 0 (幼儿园)
金币: 1137.3
红花: 1
帖子: 19
在线: 9.3小时
虫号: 2721942
注册: 2013-10-13
性别: MM
专业: 细胞信号转导

[求助] 做敲除小鼠的各种方法（细节点的，或者告诉我资源），小鼠模型对研究疾病的帮助！

Can you answer these 3 questions regarding knockout mice model and its help for disease research in as many details as possible, or give me any ideas?

1. Explain what is meant by the term “knockout mouse".

2. Describe how knockout mice are made
overall strategy
core method: traditional ways: TELENs, ZFNs, ....
new ways: CRIPSR ...

3. Give one or more examples of how they can be used to give insights into human disease.
How to use knockout mice model to give insight to human diseases？
Probelms in giving insight by using knockout mouse model?
Relevent solution?

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