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[LABORATORY/RESEARCH GROUP]:
Manalis laboratory
Departments of Biological and Mechanical Engineering
Massachusetts Institute of Technology

http://www.media.mit.edu/nanoscale/index.html
[LEADER]:
Scott Manalis
Associate Professor

[RESEARCH INTERESTS/CURRENT PROJECTS]:
The Manalis laboratory develops quantitative and real-time techniques for biomolecular detection and single cell analysis. We use conventional silicon processing techniques to fabricate fluidic devices, and exploit the unique physical properties associated with micro- and nanoscale dimensions for developing precision measurement methods.

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T.P. Burg, M.Godin, W. Shen, G. Carlson, J.S. Foster, K. Babcock, and S.R. Manalis. Weighing of Biomolecules, Single Cells, and Single Nanoparticles in Fluid. Nature, 446 1066 (2007).
R. Chunara, M. Godin, S. M. Knudsen, S.R. Manalis. Mass-based readout for agglutination assays. Applied Physics Letters, 91 193902 (2007).
T.M. Squires, R.J. Messinger, S.R. Manalis. Making it stick: convection, reaction, and diffusion in surface based biosensors. Nature Biotechnology, 26 417 (2008).

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[LABORATORY/RESEARCH GROUP]:
LangerLab
Massachusetts Institute of Technology
Department of Chemical Engineering

url:  http://web.mit.edu/langerlab/index.html
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[LEADER]:
Professor Robert S. Langer

[RESEARCH INTERESTS/CURRENT PROJECTS]:
• Investigating the mechanism of release from polymeric delivery systems with concomitant microstructural analysis and mathematical modeling.  
• Studying applications of these systems including the development of effective long-term delivery systems for insulin, anti-cancer drugs, growth factors, gene therapy agents and vaccines.  
• Developing controlled release systems that can be magnetically, ultrasonically, or enzymatically triggered to increase release rates.


ÒÔÏÂÊDz¿·Ö´ú±í×÷£¬Ã²ËÆËûûÓиüе½×îУ¬ÓÐÐËȤµÄͬѧ¿ÉÒÔµ½ËûÍøÕ¾È¥¿´Ò»¿´È«²¿µÄpublications£º

Langer, R., A bioengineer sees a future for safe gene-silencing therapies, Nature, 447:  757, 2007.

John, M., Constien, R., Akinc, A., Goldberg, M., Moon, Y., Spranger, M., Hadwiger, P., Soutschek, J., Vornlocher, H., Manoharan, M., Stoffel, M., Langer, R., Anderson, D., Horton, J., Koteliansky, V., Bumcrot, D., Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway, Nature, 449: 740-744, 2007.

Langer, R."Perspectives: Drug delivery - drugs on target", Science; 293:58-59, 2001

Kost, J., Mitragotri, S., Gabbay, R., Pishko, M., Langer, R. "Transdermal monitoring of glucose and other analytes using ultrasound", Nature Medicine; 6: 347-350, 2000

Niklason, L., Gao, J., Abbot, W., Hirschi, K., Houser, S., Marini, R., Langer, R. "Functional arteries grown in vitro", Science; 284: 489-493,1999

Santini, J., Cima, M., Langer, R."A Controlled-release Microchip", Nature; 397: 335-338, 1999

Langer, R. "Drug delivery and targeting", Nature; 392 (Supp): 5-10, 1998

Edwards, D., Hanes, J., Caponetti, G., Hrkach, J., Ben-Jebria, A, Eskew, M., Mintzes, J. Deaver, D., Lotan, N., Langer, R. "Large porous aerosols for pulmonary drug delivery", Science; 276: 1868-1871, 1997

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