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The potential value of QDs in bioimaging is due to (i) their photostability, which facilitates the long-term tracking of QD-labeled cells and molecules; (ii) their ability to tuneemission wavelength, which enables them to tag simultaneously several different population of cells and molecules; (iii) their broad excitation and narrow emission spectra, which facilitates the simultaneous detection of different QD-tagged cells; and (iv) the availability of common approaches to bioconjugate them without compromising molecular function, which allows the specific labeling of biomolecules in vivo and in vitro.These features also make QDs ideal donors in FRET – a feature that has been already tested in vitro and is likely to find widespread applications in vivo. Apprehensions about the toxicity of QDs have been an impediment to their biological application; however, several independent studies have recently demonstrated the lack of toxicity of QDs in vivo, which will enable harnessing of the potentials of QDs for in vivo applications. BeforeQDs can findwider use in biological research, several improvements must be made, including alterations of the surface properties that affect their stability in cellular environments, and developing methods for their delivery and efficient targeting in cells, without altering their properties. Although there is much that we still need to understand about these little wonders, with the current interest and the concerted efforts of physicists, chemists and biologists, it is likely that they will soon become a standard tool for biological applications. |
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lieyanbing
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2楼2009-01-17 09:50:18
lieyanbing
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3楼2009-01-17 10:05:29
lieyanbing
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4楼2009-01-17 10:05:47
尾巴色狼
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量子点在生物成像的潜在价值是由于1.他们的化学稳定性，有利于长期追踪QD标记的细胞和分子；2.他们能够调节发射波长的能力，同时,使它们能够标签的几种不同的人群细胞和分子；3.其广阔的激发范围和狭窄的发射光谱，同时发现,有利于不同QD标记的细胞；4.常见的方法就可以使他们共轭没有妥协的分子作用，允许特殊分子标记在试管内标记活泼生物大分子，这些为特征也使量子理想的捐赠者的烦恼——一种特征（那已经测试体外,并且有可能被发现广泛应用于体内） 理解关于量子点的毒性作用已经阻碍对其的生物应用；然而，最近的几个独立的研究显示毒性的量子点在体内的缺乏。这将使治理的量子点的潜力为在体内的应用。在使用量子点更加深入的应用之前，几个改进是必须的，其中包含改变他们的表面性质以提高他们在细胞环境的稳定性，并且在不改变他们细胞性质的前提下发展方法提高他们在细胞内传送和命中的几率。 尽管还有很多,我们还需要了解这些小奇迹,与当前利益和化学家，物理学家，生物学家的共同努力,他们很有可能很快就会成为一个,生物应用的标准工具 |
5楼2009-01-17 10:52:33
