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The biological transformation of the biologically active chlorogentisyl alcohol (1), isolated from the marinederived fungus Aspergillus sp., was studied. Preparative-scale fermentation of chlorogentisyl alcohol with marine-derived fungus Chrysosporium synchronum resulted in the isolation of a new glycosidic metabolite, 1-O-(aD-mannopyranosyl)chlorogentisyl alcohol (2). The stereostructure of the new metabolite obtained was assigned on the basis of detailed spectroscopic data analyses, chemical reaction, and chemical synthesis. Compounds 1 and 2 exhibited significant radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) with IC50 values of 1.0 and 4.7 mM, respectively. The compounds 1 and 2 were more active than the positive control, Lascorbic acid (IC50, 20.0 mM).  捕获.PNG |
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有机合成: 金币+50, 翻译EPI+1, ★★★★★最佳答案 2017-05-04 17:21:58
有机合成: 金币+50, 翻译EPI+1, ★★★★★最佳答案 2017-05-04 17:21:58
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The biological transformation of the biologically active chlorogentisyl alcohol (1), isolated from the marinederived fungus Aspergillus sp., was studied. Preparative-scale fermentation of chlorogentisyl alcohol with marine-derived fungus Chrysosporium synchronum resulted in the isolation of a new glycosidic metabolite, 1-O-(aD-mannopyranosyl)chlorogentisyl alcohol (2). The stereostructure of the new metabolite obtained was assigned on the basis of detailed spectroscopic data analyses, chemical reaction, and chemical synthesis. Compounds 1 and 2 exhibited significant radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) with IC50 values of 1.0 and 4.7 mM, respectively. The compounds 1 and 2 were more active than the positive control, Lascorbic acid (IC50, 20.0 mM). 对从海洋真菌Aspergillus sp分离出的生物活性物质氯代龙胆醇(1)的生物转化进行了研究。用海洋真菌Chrysosporium synchronum进行的制备级发酵分离得到新的代谢物糖苷1-O-(aD-mannopyranosyl)chlorogentisyl alcohol (2)，用详细的分光光谱数据分析，化学反应和化学合成的方法确定了这一新的代谢物的立体结构。化合物1和2都表现出显著的清除自由基1,1-diphenyl-2-picrylhydrazyl radical (DPPH)的活性， IC50值分别为1.0 和 4.7 mM。化合物1和2的清除自由基活性都比对照物L抗坏血酸 (IC50, 20.0 mM)的强。 |
2楼2017-05-03 10:53:32