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《Protein Structure Determination, Analysis, and Applications for Drug Discovery 》D. Chasman (Marcel Dekker, 2003) WW 很不错的外文书籍，喜欢的虫友请支持！ Contents Preface v Contributors xi Part I Introduction 1. Structural Biology and Structural Genomics: A Federal Agency Perspective 1 John C. Norvell and Marvin Cassman Part II Determination 2. Producing Proteins 9 Aled M. Edwards, Cheryl H. Arrowsmith, Raymond Hui, Fabien Marino, Alexei Savchenko, Ken Yamazaki, and Adelinda Yee 3. Crystallization of Membrane Proteins 27 R. Michael Garavito 4. Prospects for High-Throughput Structure Determination by X-Ray Crystallography 55 Frank von Delft, Charles D. Kang, and Duncan E. McRee 5. Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy 95 Ann E. Ferentz 6. Automated Molecular Replacement 141 Jorge Navaza and Pedro M. Alzari 7. Comparative Protein Structure Modeling 167 Andra′ s Fiser and Andrej Sali 8. Rising Accuracy of Protein Secondary Structure Prediction 207 Burkhard Rost 9. Novel Fold and Ab Initio Methods for Protein Structure Generation 251 David J. Osguthorpe Part III Analysis 10. Identifying Errors in Three-Dimensional Protein Models 277 Brian D. Marsden and Ruben A. Abagyan 11. Comparative Analysis and Evolutionary Classification of Protein Structures 315 Liisa Holm 12. Automated Genome Functional Annotation for Structural Genomics 349 Sophia Tsoka and Christos A. Ouzounis 13. The Importance of Structure-Based Function Annotation to Drug Discovery 369 Susan M. Baxter, Stacy Knutson, and Jacquelyn S. Fetrow 14. The Protein Data Bank 389 Helen M. Berman, Philip E. Bourne, John Westbrook, and Christine Zardecki 15. The European Bioinformatics Institute Macromolecular Structure Database (E-MSD) 407 Dimitris Dimitropoulos, Peter A. Keller, Kim Henrick, John Ionides, Eugene Krissinel, Philip McNeil, and Sameer S. Velankar Part IV Applications for Drug Discovery 16. Molecular Docking in Structure-Based Design 417 Trevor W. Heritage 17. Use of Pharmacophores in Structure-Based Drug Design 453 Omoshile Clement and Adrea T. Mehl 18. The Structure of Human Interferon-b-1a (Avonex1) and its Relation to Activity: A Case Study of the Use of Structural Data in the Arena of Protein Pharmaceuticals 483 Adrian Whitty and Michael Karpusas 19. G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin 521 S. Roy Kimura and Daniel I. Chasman 20. Functional Assessment of Amino Acid Variation Caused by Single-Nucleotide Polymorphisms: A Structural View 561 Daniel I. Chasman http://www.namipan.com/d/Protein%20Structure%20Determination%2c%20Analysis%2c%20and%20Applications%20-%20D.%20Chasman%20(Marcel%20Dekker%2c%202003)%20WW.pdf/2eaaabec9b5b821250bac0daf61921fa98afd1c799a25f00 |
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