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shchzh_0558铜虫 (小有名气)
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[交流]
【资源】连锁分析，SNP，单倍型等生物学分析软件下载
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http://www-gene.cimr.cam.ac.uk/clayton/software/ 下面是具体各个软件的简单介绍 Currently, the programs available are: SPLINK, a program for sib pair linkage analysis. Maximum likelihood subject to "possible triangle" restriction Marker haplotypes based on several closely linked markers Haplotype frequencies are estimated from the data TRANSMIT, a program for transmission disequilibrium testing. Marker haplotypes based on several closely linked markers Parental genotype and/or haplotype phase may be missing PED2SPL, a program for interfacing of and marker selection from standard LINKAGE input files to SPLINK and TRANSMIT. select specified markers from larger record old "binary" coding of marker genotypes handled as well as the more modern numeric coding GH2STAT, a program for processing IBD distribution files dumped by genehunter, for later analysis in statistics packages. writes a record for each pair of pedigree members considered pairs may be restricted to be both affected and/or to have IBD status which is a priori uncertain covariate and other data from the genehunter pedigree input file may also be included in the output file output file is formatted for input into SAS, Splus or R, Stata, or spreadsheet programs SNPHAP, a program for estimating frequencies of haplotypes of large numbers of diallelic markers from unphased genotype data from unrelated subjects Uses the EM algorith with "trimming" of improbable assignments Allows for missing data at some loci Can search for multiple solutions using random starting points Includes a Monte Carlo IP algorithm for multiple imputation, allowing uncertainty of solutions to be explored TDTHAP, a package for TDT with extended haplotypes in the "R" language. "R" is the public domain dialect of "S". It should be possible to port this library to the commercial "Splus" product. The main problem would be translation of the help files. [ Last edited by fishery on 2005-8-14 at 14:05 ] |
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