| 查看: 568 | 回复: 5 | |||
| 当前主题已经存档。 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
Gold nanoparticles for controlled drug delivery
|
|||
|
Using tiny gold particles and infrared light, MIT researchers have developed a drug-delivery system that allows multiple drugs to be released in a controlled fashion. Such a system could one day be used to provide more control when battling diseases commonly treated with more than one drug, according to the researchers. "With a lot of diseases, especially cancer and AIDS, you get a synergistic effect with more than one drug," said Kimberly Hamad-Schifferli, assistant professor of biological and mechanical engineering and senior author of a paper on the work that recently appeared in the journal ACS Nano. Delivery devices already exist that can release two drugs, but the timing of the release must be built into the device — it cannot be controlled from outside the body. The new system is controlled externally and theoretically could deliver up to three or four drugs. The new technique takes advantage of the fact that when gold nanoparticles are exposed to infrared light, they melt and release drug payloads attached to their surfaces. Nanoparticles of different shapes respond to different infrared wavelengths, so "just by controlling the infrared wavelength, we can choose the release time" for each drug, said Andy Wijaya, graduate student in chemical engineering and lead author of the paper. The team built two different shapes of nanoparticles, which they call "nanobones" and "nanocapsules." Nanobones melt at light wavelengths of 1,100 nanometers, and nanocapsules at 800 nanometers. In the ACS Nano study, the researchers tested the particles with a payload of DNA. Each nanoparticle can carry hundreds of strands of DNA, and could also be engineered to transport other types of drugs. In theory, up to four different-shaped particles could be developed, each releasing its payload at different wavelengths. Provided by Massachusetts Institute of Technology  The top image shows a mixture of gold nanoparticles. The longer particles are called nanobones, and the smaller are nanocapsules. Bottom left: After the nanoparticles are hit with 800 nanometer wavelength infrared light, the nanocapsules melt and release their payload. Nanobones remain intact. Right: After the nanoparticles are hit with 1100 nanometer wavelength infrared light, the nanobones melt and release their payload. Nanocapsules remain intact. Image: Andy Wijaya 论文： A. Wijaya, S. B. Schaffer, I. G. Pallares, K. Hamad-Schifferli, "Selective release of multiple DNA oligonucleotides from gold nanorods," ACS Nano, 2008, ASAP article. wijaya-la08.pdf [ Last edited by memser on 2009-1-4 at 16:06 ] |
回复此楼» 猜你喜欢
学院官方群-院士团队招生-学生自由度高-培养模式成熟已有10余名学生赴985海外深造
已经有0人回复
-
武汉纺织大学化工学院官方群-院士团队招生-学生自由度高-10余名学生赴985海外深造
已经有0人回复
-
金属材料论文润色/翻译怎么收费?
已经有192人回复
-
南昌航空大学蒋华麟教授课题组招收化学、环境、碳达峰碳中和及相关专业硕士信息
已经有0人回复
-
湖北师范大学复试调剂
已经有0人回复
-
武汉纺织大学_化工学院官方调剂群-院士团队招生-学生自由度高-每届发展好
已经有0人回复
-
河北大学材料与化工专业研究生（专硕）招收调剂生
已经有0人回复
-
河北大学无机化学专业招收调剂生
已经有0人回复
-
济南大学国家优青课题组 2026 调剂招生来啦
已经有0人回复
-
武汉纺织大学_化学院官方调剂群-院士团队招生-学生自由度高发展好-欢迎各位同学
已经有0人回复
3楼2009-01-04 12:53:38
refnew
专家顾问 (知名作家)
-
专家经验: +181 - MN-EPI: 4
- 应助: 678 (博士)
- 贵宾: 0.577
- 金币: 9465.7
- 散金: 229
- 红花: 54
- 帖子: 6391
- 在线: 1613.5小时
- 虫号: 33447
- 注册: 2003-12-31
- 性别: GG
- 专业: 纳米生物学
- 管辖: 微米和纳米
2楼2009-01-04 12:25:52
refnew
专家顾问 (知名作家)
-
专家经验: +181 - MN-EPI: 4
- 应助: 678 (博士)
- 贵宾: 0.577
- 金币: 9465.7
- 散金: 229
- 红花: 54
- 帖子: 6391
- 在线: 1613.5小时
- 虫号: 33447
- 注册: 2003-12-31
- 性别: GG
- 专业: 纳米生物学
- 管辖: 微米和纳米
4楼2009-01-04 13:59:12
5楼2009-01-04 15:04:49
