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【分享】Kaixian CHEN 院士课题组的lunwen （免费下载）
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http://www.dddc.ac.cn/publications.htm 2008 Hai-hong LI, He HUANG, Xiu-hua ZHANG, Xiao-min LUO, Li-ping LIN, Hua-liang JIANG, Jian DING, Kaixian CHEN, Hong LIU, Discovering novel 3-nitroquinolines as a new class of anticancer agents, Acta Pharmacol Sin ，Dec; 29 (12): 1529–1538, (2008) (Abstract) (PDF File) Yun Li, Pei Hao, Siyuan Zheng, Kang Tu, Haiwei Fan, Ruixin Zhu, Guohui Ding, Changzheng Dong, Chuan Wang, Xuan Li, H.-J. Thiesen, Y. Eugene Chen, Hualiang Jiang, Lei Liu and Yixue Li,Gene expression module-based chemical function similarity search, Nucleic Acids Research, Vol. 36, No. 20 e137, (2008) (Abstract) (PDF File) Guanghui Deng, Zhiguo Liu, Fei Ye, Xiaomin Luo, Weiliang Zhu, Xu Shen, Hong Liu, Hualiang Jiang, Tryptophan-containing dipeptide derivatives as potent PPARg antagonists: Design, synthesis, biological evaluation, and molecular modeling, European Journal of Medicinal Chemistry 43, 2699-2716, (2008) (Abstract) (PDF File) He Huang, Hualiang Jiang, Kaixian Chen, and Hong Liu, Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes, J. Org. Chem., 73, 9061–9064, (2008) (Abstract) (PDF File) Jiang Wang, Ting Shi, Guanghui Deng, Hualiang Jiang, and Hong Liu, Highly Enantio- and Diastereoselective Mannich Reactions of Chiral Ni(II) Glycinates with Amino Sulfones. Efficient Asymmetric Synthesis of Aromatic r,-Diamino Acids, J. Org. Chem., 73, 8563 –8570, (2008) (Abstract) (PDF File) Guanghui Deng, Weihua Li, Jianhua Shen, Hualiang Jiang, Kaixian Chen, Hong Liu, Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation, Bioorganic & Medicinal Chemistry Letters 18, 5497–5502, (2008) (Abstract) (PDF File) Diliang Guo, He Huang, Jinyi Xu, Hualiang Jiang, and Hong Liu, Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines, ORGANIC LETTERS. 10, 4513-4516, (2008) (Abstract) (PDF File) Guanghui Deng, Deju Ye, Yuanyuan Li, Lingyan He, Yu Zhou, Jiang Wang, Jia Li,Hualiang Jiang, Hong Liu, Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, Tetrahedron 64: 10512–10516, (2008) (Abstract) (PDF File) Yanqing Liu, Enkun Zhou, Kunqian Yu , Jin Zhu, Yu Zhang, Xin Xie , Jian Li Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly Molecules , 13, 2426-2441 , (2008) (Abstract) (PDF File) Ling Kang, Honglin Li, Hualiang Jiang, Xicheng Wang,An improved adaptive genetic algorithm for protein–ligand docking J Comput Aided Mol Des in press, (2008) (Abstract) (PDF File) He Huang, Xiuhua Yan, Weiliang Zhu, Hong Liu,Hualiang Jiang, and Kaixian Chen, Efficient Copper-Promoted N-Arylations of Aryl Halides with Amines, J. Comb. Chem. 10, 617–619 , (2008) (Abstract) (PDF File) Ling Kang, Honglin Li, Xiaoyu Zhao, Hualiang Jiang, Xicheng Wang, A novel conformation optimization modeland algorithm for structure-based drug design J Math Chem in press, (2008) (Abstract) (PDF File) M.-K. SONG, H. LIU, H.-L. JIANG, J.-M. YUE, G.-Y. HU AND H.-Z. CHEN, DISCOVERY OF TALATISAMINE AS A NOVEL SPECIFIC BLOCKER FOR THE DELAYED RECTIFIER K+ CHANNELS IN RAT HIPPOCAMPAL NEURONS Neuroscience 155 , 469–475, (2008) (Abstract) (PDF File) Lingyan He, Jiagao Cheng, Tao Wang, Caimei Li, Zhen Gong, Hong Liu, Bu-Bing Zeng, Hualiang Jiang, Weiliang Zhu, Cation–p complexes formed between cyclooctatetraene and alkaline earth metals: Predicted and recorded NMR features, Chemical Physics Letters 462 , 45–48 , (2008) (Abstract) (PDF File) Yechun Xu, Jacques-Philippe Colletier, Martin Weik, Hualiang Jiang, John Moult, Israel Silman, and Joel L. Sussman, Flexibility of Aromatic Residues in the Active-Site Gorge of Acetylcholinesterase: X-ray versus Molecular Dynamics, Biophysical Journal,95, 2500–2511 , (2008) (Abstract) (PDF File) Hualiang Jiang, Jiarui Wu, Lihe Zhang, Wenping Liang, Feixue Gao, Canping Du, Xuelian Feng & Yongjun Chen, Chemical biology in China takes on signal transduction, Nature Chemical Biology, 4(9), 515-518 , (2008) (Abstract) (PDF File) Li-Gen Lin, Hua Xie, Hong-Lin Li, Lin-Jiang Tong, Chun-Ping Tang, Chang-Qiang Ke, Qun-Fang Liu, Li-Ping Lin, Mei-Yu Geng, Hualiang Jiang, Wei-Min Zhao, Jian Ding, and Yang Ye, Naturally Occurring Homoisoflavonoids Function as Potent Protein Tyrosine Kinase Inhibitors by c-Src-Based High-Throughput Screening. J. Med. Chem. , 51, 4419–4429 , (2008) (Abstract) (PDF File) Tiancen Hu, Dalei Wu, Jing Chen, Jianping Ding, Hualiang Jiang, and Xu Shen, The Catalytic Intermediate Stabilized by a “Down” Active Site Loop for Diaminopimelate Decarboxylase from Helicobacter pylori, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 283, 30, 21284 –21293, (2008) (Abstract) (PDF File) Li Du, Liangliang Shen, Zhiguo Yu, Jing Chen, Yuewei Guo, Yun Tang, Xu Shen, and Hualiang Jiang, Hyrtiosal, from the Marine Sponge Hyrtios erectus, Inhibits HIV-1 Integrase Binding to Viral DNA by a New Inhibitor BindingSite. ChemMedChem , 3, 173 – 180 (2008) (Abstract) (PDF File) Dalei Wu, Liang Zhang, Yunhua Kong, Jiamu Du, Shuai Chen, Jing Chen,Jianping Ding, Hualiang Jiang, and Xu Shen, Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori. Proteins; 72:1148–116 (2008) (Abstract) (PDF File) 王江, 邓光辉, 柳红, 蒋华良, Ni(II)螯合物在氨基酸合成中的应用, 有机化学, 28 (7), 138～1144 (2008) (Abstract) (PDF File) Zhaoguang Li, Hongbin Sun, Hualiang Jiang, and Hong Liu, Copper-Catalyzed Intramolecular Cyclization to N-Substituted 1,3-Dihydrobenzimidazol-2-ones, Organic Letters, 10 (15), 3263-3266 (2008) (Abstract) (PDF File) He Huang, Hong Liu, Hualiang Jiang, and Kaixian Chen, Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides J. Org. Chem. 73, 6037–6040 (2008) (Abstract) (PDF File) Xiaoyu Zhao, Xiaofeng Liu, Yuanyuan Wang, Zhi Chen, Ling Kang, Hailei Zhang,Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Honglin Li, Xicheng Wang, and Hualiang Jiang, An Improved PMF Scoring Function for Universally Predicting the Interactions of a Ligand with Protein, DNA, and RNA. J. Chem. Inf. Model. 48, 1438–1447 (2008) (Abstract) (PDF File) 程家高, 罗小民, 闫秀花, 李忠, 唐赟, 蒋华良, 朱维良, 阳离子-π作用的研究进展, 中国科学 B 辑:化学,38,4: 269 ~ 277 (2008) (Abstract) (PDF File) CHENG JiaGao, LUO XiaoMin, YAN XiuHua, LI Zhong, TANG Yun, JIANG HuaLiang1,& ZHU WeiLiang, Research progress in cation-π interactions, Science in China Series B: Chemistry, 709-717 (2008) (Abstract) (PDF File) 程家高, 朱维良, 王岩丽, 闫秀花, 李忠, 唐赟, 蒋华良,A型流感病毒M2通道蛋白开闭机制: His37和Trp41间的氢键及阳离子-π作用的计算研究, 中国科学 B 辑:化学,38,4: 340 ~ 346 (2008) (Abstract) (PDF File) CHENG JiaGao, ZHU WeiLiang, WANG YanLi, YAN XiuHua, LI Zhong, TANG Yun& JIANG HuaLiang, The open-close mechanism of M2 channel protein in influenza A virus: A computational study on the hydrogen bonds and cation-π interactions among His37 and Trp41 , Science in China Series B: Chemistry, 768-775 (2008) (Abstract) (PDF File) Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang, Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes, PLoS ONE 3,7, e2697 (2008) (Abstract) (PDF File) Jing Ai, Xianliang Xin, Mingyue Zheng, Shuai Wang, Shuying Peng,JingLi, Limei Wang, Hualiang Jiang, Meiyu Geng,A Triad of Lys12, Lys41, Arg78 Spatial Domain, a NovelIdentified Heparin Binding Site on Tat Protein, Facilitates Tat-Driven Cell Adhesion, PLoS ONE 3,7, e2662 (2008) (Abstract) (PDF File) Xiao-Ling Yu, Tiancen Hu, Jia-Mu Du, Jian-Ping Ding, Xiang-Min Yang, Jian Zhang, Bin Yang, Xu Shen,Zheng Zhang, Wei-De Zhong, Ning Wen, Hualiang Jiang, Ping Zhu, and Zhi-Nan Chen, Crystal Structure of HAb18G/CD147: IMPLICATIONS FOR IMMUNOGLOBULIN SUPERFAMILY HOMOPHILIC ADHESION, THE JOURNAL OF BIOLOGICAL CHEMISTRY . 283, 26, 18056–18065, (2008) (Abstract) (PDF File) Deju Ye, Guanghui Deng, Wenfeng Liu, Yu Zhou, Enguang Feng, Hualiang Jiang, Hong Liu, Simultaneous 2-O-deacetylation and 4-amination of peracetylated Neu5Ac: application to the synthesis of (4/4)-piperazine derivatives linked sialic acid dimers, Tetrahedron 64, 6544–6550 (2008) (Abstract) (PDF File) Zhaoguang Li, He Huang, Hongbin Sun, Hualiang Jiang, and Hong Liu, Microwave-Assisted Efficient and Convenient Synthesis of 2,4(1H,3H)-Quinazolinediones and 2-Thioxoquinazolines, J. Comb. Chem., 10, 484–486 (2008) (Abstract) (PDF File) Shiyu Chen, He Huang, Xuejun Liu,Jingkang Shen, Hualiang Jiang, and Hong Liu , Microwave-Assisted Efficient Copper-Promoted N-Arylation of Amines with Arylboronic Acids, J. Comb. Chem. 10, 358–360 (2008) (Abstract) (PDF File) Xiao-Ling Yu, Tiancen Hu, Jia-Mu Du, Xiang-Min Yang, Jian Zhang, Bin Yang,Xu Shen, Zheng Zhang, Wei-De Zhong, Ning Wen, Jian-Ping Ding, Hualiang Jiang,Ping Zhu, and Zhi-Nan Chen, CRYSTAL STRUCTURE OF HAb18G/CD147: IMPLICATIONS FOR IMMUNOGLOBULIN SUPERFAMILY HOMOPHILIC ADHESION, J. Bio. Chem. , in press (2008) (Abstract) (PDF File) Xinli Liu, Yechun Xu, Xicheng Wang, Francisco J. Barrantes, and Hualiang Jiang,Unbinding of Nicotine from the Acetylcholine Binding Protein: Steered Molecular Dynamics Simulations, J. Phys. Chem. B, 112, 4087-4093.(2008) (Abstract) (PDF File) Zeng, J., Li, W., Zhao, Y., Liu, G., Tang, Y. and Jiang, H. Insights into ligand selectivity in estrogen receptor isoforms: molecular dynamics simulations and binding free energy calculations.J Phys Chem B,112: 2719-2726.(2008) (Abstract) (PDF File) Weihua Li, Yun Tang, Hong Liu, Jiagao Cheng, Weiliang Zhu, and Hualiang Jiang, Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking, Proteins, 71:938–949., (2008) (Abstract) (PDF File) Zhao-bing GAO, Xue-qin CHEN, Hua-liang JIANG, Hong LIU, Guo-yuan HU, Electrophysiological characterization of a novel Kv channel blocker N,N’-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl ) ]bis(4-methyl ) -benzenesulfonamide found in virtual screening, Acta Pharmacol Sin 29 (4): 405–412, (2008) (Abstract) (PDF File) YECHUN XU, JACQUES PH. COLLETIER, HUALIANG JIANG,ISRAEL SILMAN, JOEL L. SUSSMAN,AND MARTIN WEIK, Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design. Protein Science , 17:601–605., (2008) (Abstract) (PDF File) Liang Zhang, Weizhi Liu, Tiancen Hu, Li Du, Cheng Luo, Kaixian Chen, Xu Shen, and Hualiang Jiang,Structural Basis for Catalytic and Inhibitory Mechanisms of beta-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ),JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 9, 5370–5379, (2008) (Abstract) (PDF File) Zhenting Gao, Honglin Li, Hailei Zhang, Xiaofeng Liu, Ling Kang, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Xicheng Wang & Hualiang Jiang. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 9:104 (2008) URL Jian Li, Deju Ye, Hong Liu, Xiaomin Luo, and Hualiang Jiang Microwave-Assisted Dehalogenation of a-Haloketones by Zinc and Ammonium Chloride in Alcohol,Synthetic Communications, 38: 567–575, (2008) (Abstract) (PDF File) Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang, Francisco J. Barrantes, Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor,PLoS Comput Biol 4(1):e19, (2008) (Abstract) (PDF File) Ling Chen ; Mingfang Zheng; Yu Zhou; Hong Liu ; Hualiang Jiang, Ionic-Liquid-Supported Total Synthesis of Sansalvamide A Peptide .Synthetic Communications, 38: 239–248, (2008) (Abstract) (PDF File) Shuai Chen, Tiancen Hu, Jian Zhang, Jing Chen, Kaixian Chen, Jianping Ding, Hualiang Jiang and Xu Shen, Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS .J. Biol. Chem , 283. 554–564, (2008) (Abstract) (PDF File) [ Last edited by zdhlover on 2009-11-30 at 15:20 ] |
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