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Since CDs are ¡°selectors¡± optimizations should not be done in terms of Rs but also using ¡°selectivities¡± (alphas), or any other optimization criterion based on mobilities.
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CD concentrations are two (new) separation variables as it also are pH, voltage, ionic strength, or injection volume. This is an interesting and novel proposal. There are two conceptual lines that could be followed to optimize them: investigating the dependencies of the mobilities on the different variables ¨C e.g. mu vs [CD1], mu vs [CD2], mu vs pH, etc... ¨C to compose a model predicting mu=f ([CD1], [CD2], pH, etc) to finally optimize mathematically ¨C e.g. by maximization of predicted selectivities between all pairs-, or exploring empirically all the responses in all the domains of the selected variables ¨C e.g. selectivities between all pairs at different levels within the domains of the selected variables ¨C e.g. experimental selectivities vs ([CD1], [CD2], pH, etc..)-
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