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11Â¥2017-03-08 21:21:26
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12Â¥2017-03-08 21:30:04
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13Â¥2017-03-08 21:35:31
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13Â¥: Originally posted by ÇÉÃöù1993 at 2017-03-08 21:35:31
ÓÐÄÜÁ¦Çø±ðÊÇ·ñÔÚDZÔÚϸ°û°ÐÄ¿±ê¼¤Ã¸µÄÒÖÖÆ¼Á, on,offÐÞÊεÄÊÇpotential  cellual,¶ø²»ÊǺóÃæµÄtarget,Ò»¿ªÊ¼ÌýÄãÕâô˵ҲºýÍ¿ÁË£¬À¨ºÅ²»ÊÇ×¢½âÇ°ÃæµÄÂ¸öÈË¿´·¨£¬½ö¹©²Î¿¼¡£
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on-target ºÍoff-targetÔÚÎÄÏ×ÀïÃæÊÇÓÐÕâÖÖ±íÊöµÄ£¬±ÈÈç˵Õâ¾ä»°Results herein thus provide important information for studying potential cellular off-targets of staurosporine in future. ÔÙ±ÈÈç˵Õâ¾ä»°In many cases, drugs have multiple protein targets, and identification of the complete target spectrum of a drug provides the most valuable information on the so-called ¡°off-targets¡± of the drug, which are unexpected protein targets that may lead to unwanted biological alterations and toxicity. ËùÒÔÄãÕâ¸ö½âÊÍÒ²ÓÐЩǷÍ×
14Â¥2017-03-08 22:07:07
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15Â¥2017-03-08 23:05:58
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16Â¥2017-03-08 23:20:38
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Proteomics¼ø¶¨³öµÄËùνµÄ°Ðµã»á³öÏÖ¼ÙÑôÐÔ½á¹û£¬off-target×ÖÃæÒâ˼ÊÇÍѰУ¬Ö¸µÄÊǼ¤Ã¸ÒÖÖÆ¼ÁµÄ¼ÙÑôÐ԰еã
17Â¥2017-03-09 11:09:17
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17Â¥: Originally posted by ¸¶Ö®ÎÄ at 2017-03-09 11:09:17
Proteomics¼ø¶¨³öµÄËùνµÄ°Ðµã»á³öÏÖ¼ÙÑôÐÔ½á¹û£¬off-target×ÖÃæÒâ˼ÊÇÍѰУ¬Ö¸µÄÊǼ¤Ã¸ÒÖÖÆ¼ÁµÄ¼ÙÑôÐ԰еã

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18Â¥2017-03-09 11:24:09
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³Â±ë: ½ð±Ò+3 2017-03-09 22:44:10
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18Â¥: Originally posted by ³Â±ë at 2017-03-09 11:24:09
ÄãµÄÒâ˼ÊÇon-targetÖ¸µÄÊÇÕæÕýµÄ°Ð±ê£¬off-targetÊǼÙÑôÐ԰бꣿ...

²»ÊÇ£¬¿´ÍêÄã²¹³äµÄ×ֶΣ¬Õâ¸öoff-targetÖ¸µÄ¾ÍÊÇÍѰУ¬ÓкܶàÒ©ÎïµÄ¸±×÷ÓÃÊÇÒòΪÍѰÐЧӦÒýÆðµÄ£¬proteomicsÊÖ¶ÎÒ²¿ÉÒÔ°ÑÕâЩ°Ðµã¸ø¼ø¶¨³öÀ´
19Â¥2017-03-09 16:27:21
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19Â¥: Originally posted by ¸¶Ö®ÎÄ at 2017-03-09 16:27:21
²»ÊÇ£¬¿´ÍêÄã²¹³äµÄ×ֶΣ¬Õâ¸öoff-targetÖ¸µÄ¾ÍÊÇÍѰУ¬ÓкܶàÒ©ÎïµÄ¸±×÷ÓÃÊÇÒòΪÍѰÐЧӦÒýÆðµÄ£¬proteomicsÊÖ¶ÎÒ²¿ÉÒÔ°ÑÕâЩ°Ðµã¸ø¼ø¶¨³öÀ´...

´óÏÀÎÒ»¹ÊÇÓе㲻̫¶®off-targetµÄº¬Ò壬Äܲ»ÄܸøÎÒ½²ÏÂÄã¶ÔÕâ¸ö´ÊµÄÀí½â£¬ÁíÍâ°ïÎÒ¿´ÏÂÏÂÃæ3¾ä»°ÖÐoff-target¸÷×Եĺ¬Ò壬Âé·³ÁË£¡²»Ê¤¸Ð¼¤£¡
1¡¢However, potential side effects of Orlistat, such as inhibition of other cellular off-targets or poor bioavailability, might hamper its application as an effective antitumor agent.
2¡¢To this end, the research group of Yao undertook an ABPP approach to look for new cellular targets of Orlistat, including its off-targets.
3¡¢3-Deazaneplanocin A is a global histone methylation inhibitor, whose molecular mechanism of action and cellular off-targets were not fully understood.
20Â¥2017-03-09 22:43:55
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