Oxidative Stress, Disease and Cancer
By Keshav K. Singh


Publisher:  Imperial College Press
Number Of Pages:  1104
Publication Date:  2006-04-01
ISBN-10 / ASIN:  1860946097
ISBN-13 / EAN:  9781860946097
Binding:  Hardcover



Product Description:

This book aims to provide a comprehensive review of the most up-to-date knowledge of the sources and molecular mechanisms of oxidative stress, and its role in disease and cancer. It also focuses on the novel agents and methods that can be employed to prevent oxidative stress and associated diseases.

The authors first review the most recent data on the basic mechanisms of oxidative stress. The second section discusses oxidative stress leading to several diseases and cancers, and in the third section, the strategies employed in the prevention and treatment of oxidative stress-related diseases are discussed.

BASIC MECHANISMS
1. Yin and Yang of Mitochondrial ROS 1
Anatoly Starkov and Kendall B. Wallace
2. Intracellular Oxidative Stress Caused by Ionizing Radiation 61
Hideyuki J. Majima, Hiroko P. Indo, Kazuo Tomita, Shigeaki
Suenaga, Shigeatsu Motoori, Hirotoshi Kato,
Hsiu-Chuan Yen, and Toshihiko Ozawa
3. Oxidative Damage to Mitochondria 85
Jai C. Tilak and Thomas P.A. Devasagayam
4. Oxidative Stress and Antioxidant Defenses in Plants 151
Olga Blokhina and Kurt Fagerstedt
5. Lipid- and Protein-Mediated Oxidative Damage to DNA 201
Mark D. Evans and Marcus S. Cooke
6. Oxidative Damage to Nucleotide: Consequences and
Preventive Mechanisms 221
Yoshimichi Nakatsu and Mutsuo Sekiguchi
7. Oxidative Damage to DNA and Its Repair 253
Lene Juel Rasmussen
8. Cellular Responses to Reactive Oxygen Species 281
Ian W. Dawes
9. Oxidative Stress, Cell Proliferation, and Apoptosis 309
Jennifer S. Carew, Yan Zhou, and Peng Huang
10. Oxidative Damage to Carbohydrates and Amino Acids 333
Marco d¡¯Ischia, Paola Manini, and Alessandra Napolitano
11. Superoxide Dismutase 2 Deficient Mice: The Role of
Increased Reactive Oxygen Species in Genomic
Instability 357
Enrique Samper, Chris Benz, and Simon Melov
DISEASE
12. Oxidative Stress, Genetic Variation, and Disease 371
Louise Lyrenäs, Elena Zotova, Lena Ekström,
and Ralf Morgenstern
13. Oxidative Stress and Autoimmune Diseases 461
Jun Saegusa, Seiji Kawano and Shunichi Kumagai
14. Does Oxidative Stress Determine Lifespan? 477
Florian L. Muller and Holly Van Remmen
15. Oxidative Stress and Ataxia¨CTelangiectasia 499
Emily M. Dunner and Dianne J. Watters
16. Oxidative Stress and Cardiovascular Disease 519
Sofian Johar, Philip A. MacCarthy, and Ajay M. Shah
17. Oxidative Stress, Insulin Resistance, and
Cardiovascular Disease 537
Antonio Ceriello
18. Pathogenesis and Etiology of Down¡¯s Syndrome in Relation
to Oxidative Stress 557
Svetlana Arbuzova and Howard Cuckle
19. Oxidative Stress and Ulcerative Colitis: Experimental
Evidence and Implications for Treatment 577
Darren N. Seril, Jie Liao, Guang-Yu Yang, and
Chung S. Yang
Contents ix
20. Oxidative Stress and Neurodegenerative Disease 627
Katrin Sch¨¹ssel, Uta Keil and Anne Eckert
21. Oxidative Stress and Mitochondrial Disease 649
Ching-You Lu, Cheng-Feng Lee, Yi-Shing Ma,
Chun-Yi Liu, Chia-Yu Wei, Yin-Chiu Chen, Shi-Bei Wu,
and Yau-Huei Wei
22. Oxidative Stress and Respiratory Disease 673
Rosario Maselli and Girolamo Pelaia
23. Oxidative Stress and Human Reproduction 687
Ashok Agarwal and Shyam Allamaneni
24. Oxidative Stress and Multistage Carcinogenesis 705
Prabhat C. Goswami and Keshav K. Singh
25. Oxidative Stress and Cancer Cachexia 733
Giovanni Mantovani and Clelia Madeddu
26. Oxidative Stress in Cancer-Prone Diseases 761
Giovanni Pagano
27. Iron-Induced Carcinogenesis 789
Shinya Toyokuni
28. Copper and Carcinogenesis 807
Theophile Theophanides and Jane Anastassopoulou
29. Arsenic, Oxidative Stress, and Carcinogenesis 825
Michael F. Hughes and Kirk T. Kitchin
30. Estrogen-Induced Carcinogenesis: Importance of
Oxidative Stress 851
Hari K. Bhat
31. Oxidative Stress in HIV Infection 885
Wulf Dröge
32. Oxidative Stress and Breast Cancer 897
Jiyoung Ahn and Christine B. Ambrosone
33. Oxidative Stress and Photocarcinogenesis: Strategies
for Prevention 933
Santosh K. Katiyar
34. Oxidative Stress and Coenzyme Q10 Therapy 965
Franklin L. Rosenfeldt, Silvana Marasco, Jee-Yoong Leong,
and Salvatore Pepe
35. Plant-Derived Antioxidants 995
Fazlul H. Sarkar and Yiwei Li
PREVENTION AND TREATMENT
36. Oxidative Stress and Cancer Therapy 1013
Kevin Pong
37. Nanoscale Antioxidant Therapeutics 1023
Thomas Dziubla, Silvia Muro, Vladimir R. Muzykantov,
and Michael Koval
38. Use of Biomarkers of Oxidative Stress in Human Studies 1045
Chung-Yen Chen and Jeffrey B. Blumberg
Index 1077