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燕山大学栗坤教授课题组招生
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课题组简介 课题组目前现有研究人员10余人，其中包括留美归国教师、毕业于香港大学的博士后和研究生等。带头人栗坤教授，燕山大学毕业，研究生学历，博士学位。中国抗癌协会纳米肿瘤学专业委员会委员和精准医学与肿瘤康复专业委员会委员。目前研究工作主要在肿瘤早期检测方面既寻找可直接示踪癌症的发生和发展过程中标志物，并能实现对这些标志物高灵敏度的检测，对肿瘤的早期诊断和治疗具有非常重要的科学意义和临床价值；抗癌药物载体制备方面既构建稳定性高和靶向性好的脂质体载药系统可以减少药量，降低副作用，提高药效。作为项目主要参与人与负责人曾承担河北省秦皇岛市科学技术研究与发展计划项目、省自然科学基金项目、省卫生厅项目、军口“863”课题、国家重大转基因专项等。.近几年，在国内外学术刊物共发表肿瘤研究相关领域SCI收录论文30余篇；申请专利4项，其中授权1项。 |
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研究方向： 1. 血清肿瘤标志物核酸适配体的筛选及其检测技术的研究； 2. 肿瘤特异靶向性纳米药物载体的研究； 招收的研究生专业：药学、化学、化工、生物、医学等相关专业，欢迎学生报考和调剂。 邮箱：likun@ysu.edu.cn |
2楼2017-01-06 12:07:13
3楼2017-01-06 12:07:25
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近期已发表的学术论文： 1.Kun Li, Haizhao Zhang, Liming Gao, Yue Zhai, Ming Shi, Jian Li, Chenlin Xiu, Junli Cao, Shaohui Cheng, Li Jiang, and Hao Di. Preparation and Characterization of Baicalein-Loaded Nanoliposomes for Antitumor Therapy. Journal of Nanomaterials, 2016, Article ID 2861915, 9 pages. 2.Li Kun, Xiu Chenlin, Gao Liming, Shiming, ZHAI Yue. Subtractive SELEX using agar beads for screening DNA aptamers with specifics affinity to HIV gp41 antigen. J South Med Univ, 2016, 36(12): 1592-1598. 1 .Li K, Li QW, Han ZS, Li J, Gao DW, Liu ZW, Zheng F. Alkaloid from Angelicae dahuricae inhibits HeLa cell growth by inducing apoptosis and increasing caspase-3 activity. LABMEDICINE 2008,39(9):540-546. 2. Li K, Li QW, Li J, Zhang T, Han ZS, Gao DW, Zheng F. Antitumor activity of the procyanidins from Pinus koraiensis bark on mice bearing U14 cervical cancer. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007127(7):1145-1151. 3.Kun Li, Qingwang Li, Tao Zhang, Zengsheng Han, Jian Li, Zhiwei Liu and Fulu Zheng. Procyanidins from Pinus Koraiensis bark inhibits HeLa cell growth by inducing apoptosis and reducing survivin protein expression. African Journal of Biotechnology, 2011, 10(40): 7766-7771. 4.KUN LI, LIU YANG, HAIFENG ZHAO, JIANJIE WANG,YONG PENG, ZENGSHENG HAN and TAO ZHANG. Effects of Alkaloid from Angelicae Dahuricae Inducing Apoptosis and Increasing Bax/Bcl-2 Ratio on HeLa Cell. International Conference on Frontiers of Environment, Energy and Bioscience (ICFEEB 2013) ISBN: 978-1-60595-133-1. 5.Kun Li, Jie Wang, Ming Shi, Jian Li, Li Yan, Haizhao Zhang, Chengbiao Lu. Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo. JBUON, 2015, 20(5):1368-1372. 6. Li A, Li Q, Feng T, Zhang T, Li K, Zhao R, Han Z, Gao D. Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice. PHYTOTHERAPY RESEARCH, 2007,21(9):832-840. 7. Yong Peng, Qingwang Li, Kun Li, Hongwei Zhao, zengsheng Han, Fenglin Li, Man Sun and Yanxia Zhang. Antitumor activity of baicalein on the mice bearing U14 cervical cancer. African Journal of Biotechnology, 2011, 10(64): 14169-14176. 8. Jianjie Wang, Qingwang Li, Kun Li, Yetao Ou, Zengsheng Han, Dawei Gao, Jian Li. Effects of Adenovirus Vectors Mediated Human Lactoferrin cDNA on Mice Bearing EMT6 Breast Carcinoma. Die pharmazie, 2011,66(9):704-709. 9. PEIJUN WANG, QINGWANG LI, Kun Li, XiaoBo ZHANG, ZENGSHENG HAN, JIANJIE WANG, DAWEI GAO, JIAN LI. Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma(U14) tumor-bearing mice. pharmazie,2012,67:733-739. 10.Yetao Ou, Qingwang Li, Jianjie Wang, Kun Li and Shaobo Zhou. Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. BIOMOLECULES & THERAPEUTICS, 2014, 22(4): 341-346. 11. Li J, Li QW, Feng T, Li K. Aqueous extract of Solanum nigrum inhibit growth of cervical carcinoma (U14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor cells. FITOTERAPIA, 200879(7-8):548-556. 12. Jianjie Wang, Qingwang Li, Yetao Ou, Zengsheng Han, Kun Li, Peijun Wang, and Shaobo Zhou. Inhibition of Tumor Growth by Recombinant Ahenovirus Containing Human Lactoferrin through Inducing Tumor Cell Apoptosis in Mice Bearing EMT6 Breast Cancer. Arch Pharm Res, 2011, 34(6): 987-995. |
4楼2017-01-06 12:07:39
