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求助文章翻译(英译汉，生物相关)
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急用，希望大家能给正确的中文版本， The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events http://www.namipan.com/d/373.pdf/dc5b03a699d13a8367118ba16c48f084945825269c8d0300 |
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3楼2008-12-14 18:35:17
caitikuan
木虫 (小有名气)
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只翻译摘要（6页正文太多了，做生物还是直接看原文比较好）
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The role of the CD44 transmembrane and cytoplasmic domains in coordinating adhesive and signalling events CD44的跨膜区和胞质区在配位粘连和信号转导中的作用 CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major hyaluronan receptor on most cell types. CD44的是一种广泛分布I型跨膜糖蛋白其在大多数细胞类型中的主要功能作为透明质酸受体。 Although alternative splicing can produce a large number of different isoforms, they all retain the hyaluronan-binding Link-homology region and a common transmembrane and cytoplasmic domain, which are highly conserved between species. 虽然选择性剪接就可以生产出大量不同的亚型，它们都保留透明质酸结合链同源区和一个共同的跨膜区和胞质区，物种之间这是高度保守的。 The past decade has seen an extensive investigation of this receptor owing to its importance in mediating cell-cell and cell-matrix interactions in both normal and disease states. 在过去十年中该受体被得到广泛研究，由于其重要性在于在正常和疾病状态调解细胞间和细胞与基质间的相互作用。 Although roles for alternative splicing and variable glycosylation in determining ligand-binding interactions are now well established, the mechanisms by which CD44 integrates structural and signalling events to elicit cellular responses have been less well understood. 虽然选择性剪接和可变糖基化在配体结合反应中的作用已知道，但是CD44的结合结构和信号转导引起细胞的反应的机理都不太了解。 However, there is now increasing evidence that CD44 is assembled in a regulated manner into membrane-cytoskeletal junctional complexes and, through both direct and indirect interactions, serves to focus downstream signal transduction events. 然而，现在越来越多的证据表明CD44的装配以一种调控模式嵌入膜骨架复合物，并通过直接和间接的相互作用为下游信号转导重点服务。 |
2楼2008-12-10 16:20:40
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