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Postdoctoral Fellow position at Thomas Jefferson University
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A Postdoctoral Fellow position is available immediately in the Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Our research areas of interests are to identify novel signaling pathways and mechanisms that regulate tumor initiation, angiogenesis, and development. We will focus on the study and mechanism of initiation and progression of human cancers that are induced by environmental factors, such as metal carcinogens. Through this program, we will identify new mechanisms, biomarkers, and/or therapeutic targets for cancer prevention and treatment in the future. Our group initially finds that PI3K signaling pathway, ROS and miRNAs play important roles in tumor angiogenesis and drug resistance. For more information, please read some of our related work in Cancer Res. 67(22):10823, 2007; EMBO Rep. 13(12):1116, 2012; Autophagy. 11(2):373, 2015; Oncogene. 34(43):5482, 2015; Toxicol Sci. 134(1):26, 2013; Environ Health Perspect. 122(3):255, 2014; Oncotarget. 7(14):17805, 2016. For the Postdoctoral Fellow position, a Ph.D. degree in molecular biology or other biomedical science with good research experience is required. We greatly appreciate the application from candidates from minority groups or with good experience in tumor microenvironment, database analysis, or/and 1-4 years of training in USA. We have enough funding support for this position and have close collaboration with Dr. Bing-Hua Jiang (https://www.ncbi.nlm.nih.gov/pubmed/?term=jiang+bh) in our department. Our Institute offers excellent research environment, and competitive salary based on experience and effort. For consideration, please send your curriculum vitae, and the names of three references to: Dr. Ling-Zhi Liu at Ling-Zhi.Liu @jefferson.edu. Selected publication (https://www.ncbi.nlm.nih.gov/pubmed/?term=liu+ling-zhi) : Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy. He J, Yu JJ, Xu Q, Wang L, Zheng JZ, Liu LZ, Jiang BH. Autophagy. 2015;11(2):373-84. Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1α/COX-2 pathway. He J, Wang M, Jiang Y, Chen Q, Xu S, Xu Q, Jiang BH, Liu LZ. Environ Health Perspect. 2014 Mar;122(3):255-61. Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1. Yin Y, Yan ZP, Lu NN, Xu Q, He J, Qian X, Yu J, Guan X, Jiang BH, Liu LZ. Biochim Biophys Acta. 2013 Feb;1829(2):239-47. A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Xu Q, Jiang Y, Yin Y, Li Q, He J, Jing Y, Qi YT, Xu Q, Li W, Lu B, Peiper SS, Jiang BH, Liu LZ. J Mol Cell Biol. 2013 Feb;5(1):3-13. doi: 10.1093/jmcb/mjs049. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, Li Q, Wang XR, Peiper SS, Lu Z, Liu LZ, Jiang BH. EMBO Rep. 2012 Dec;13(12):1116-22. Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis. Liu LZ, Zheng JZ, Wang XR, Jiang BH. Cancer Res. 2008 Oct 1;68(19):8183-8. doi: 10.1158/0008-5472.CAN-08-0819. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Liu LZ, Zhou XD, Qian G, Shi X, Fang J, Jiang BH. Cancer Res. 2007 Jul 1;67(13):6325-32. |
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