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Determination of drug release rates from different film formulation was carried out using a diffusion cell. Complete media replacement method was used to maintain sink condition throughout the study period[18]. Egg shell membrane previously soaked for 24 h in phosphate buffer (pH 6.8) was stretched around one end of the tube. Donor compartment was assembled into a glass beaker (receptor compartment) with the membrane just touching the receptor medium. One cm2 film was introduced into the donor tube ÏëÎÊÏ ÎÄÏ×ÖÐ×öµÄÌåÍâÊͷŵķ½·¨ÊÇÔõô×öµÄ ÎÒû¿´Ì«¶® |
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