24小时热门版块排行榜

南方科技大学公共卫生及应急管理学院2025级博士研究生招生报考通知

返回列表

【奖励】本帖被评价5次，作者qqqqqq123456增加金币 4.5 个

当前主题已经存档。

qqqqqq123456

至尊木虫 (职业作家)

应助: 7 (幼儿园)
金币: 39142.4
帖子: 4540
在线: 948.1小时
虫号: 93186

[资源] 【分享】HyperProtein V1.0

HyperProtein is Hypercube, Inc.'s new product focusing on the computational science associated with protein sequences.  The product includes the analysis of one-dimensional protein sequences as well as the analysis of consequent three-dimensional protein structures.  In particular, the relationship between sequence and structure is a fundamental  facet of the product.  Unlike individual software programs that provide capability for some aspect of protein sequence or structure, such as sequence alignment, HyperProtein puts together a multitude of Bioinformatics and Molecular Modeling tools related to the science that initiates with a protein sequence.

HyperProtein brings protein simulation to a whole new level. Utilizing graphics, molecular mechanics, and various molecular modeling features, HyperProtein transforms the world of sequencing to a world of 3-dimensional modeling, putting molecular evolution at our fingertips.

HyperProtein starts with a sequence or a set of sequences representing a protein family.  That is,  it  manipulates and analyses a family of homologous proteins representative of different species.  It aligns these sequences, builds a phylogenetic tree for the species and generates the sequences for the ancestral species in the tree.  It then allows you to explore the differences along an evolutionary branch of  the tree including exploring the changes in a three dimensional protein structure representative of the protein family.  Do changes to protein structure from mouse to human occur on the surface, at the active site, etc? How does evolution affect the 3D functionality of proteins?

While the global problem of a priori prediction of protein structure from sequence is unsolved, HyperProtein allows exploration of this important problem.  It uses neural nets to predict secondary structure from sequence.  It allows molecular mechanics optimization of any structure large or small.  It generates a candidate 3D structure of a protein from sequence when the structure of a homologous protein is available. Combine sequence analysis and molecular modeling!

Features:

Multi-Windowed application that allows a Project and GUI approach to Bioinformatics and Phylogenetics.

Connection of Bioinformatics to Molecular Modeling.

All the features of HyperChem that are relevant to proteins are included in HyperProtein.

Various manipulations, analyses, and displays of protein sequences.

Multi-sequence analysis (MSA) of protein families.

Creation and display of evolutionary changes in proteins via phylogenetic trees created from MSAs.

Analysis of three-dimensional consequences of evolutionary changes occuring in protein sequences.

Direct connection between protein sequence changes and 3D changes in representative protein structures.

Prediction of secondary structure from primary sequence.

Integrated graphical analysis of sequences and their properties.

下载办法：
点击下载

[url=http://www.hyper.com/Portals/0/Downloads/Products/HyperProtein.zip/url]

安装时请选用standalone---harware protection
系列号使用：15-100-1501799999

安装完成后使用本附件所带文件覆盖C：\hyperprotein\program\hyperprotein.exe 文件后即完成破解。

该软件为本人破解，不足之处请指正！

[ Last edited by fegg7502 on 2009-12-9 at 23:19 ]

回复此楼